{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:20:33Z","timestamp":1787793633957,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503012"],"award-info":[{"award-number":["82503012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This prospective randomized controlled trial aimed to evaluate the clinical value of recombinant bovine basic fibroblast growth factor (rb\u2010bFGF)\u2010based combined therapy in hair transplantation, focusing on its optimization effects on follicle survival rate, postoperative hair\u2010loss dynamics, complication control, and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients with moderate\u2010to\u2010severe androgenetic alopecia were randomly assigned to either an rb\u2010bFGF group or a control group. In the rb\u2010bFGF group, harvested follicles were intraoperatively immersed in an rb\u2010bFGF\u2013enriched solution and patients received postoperative topical rb\u2010bFGF gel for 3\u2009weeks, in addition to baseline medications and minoxidil. Control group follicles were stored in saline, with postoperative minoxidil alone. Quantitative assessments include measurements of hair follicle viability and hair density at 3, 6, and 12\u2009months postoperatively. Patient satisfaction was assessed using a three\u2010level scale, and complication rates were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rb\u2010bFGF group demonstrated superior outcomes compared with controls, including higher 12\u2010month follicle survival (91.1% vs. 81.0%), lower hair\u2010loss rate (11.6% vs. 22.7%), greater patient satisfaction (96.7% vs. 80.0%), and fewer complications (20.0% vs. 85.3%). All differences were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intraoperative follicle immersion and postoperative topical application of rb\u2010bFGF significantly enhance graft survival, reduce early hair loss, decrease complications, and improve overall outcomes in hair transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70464","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:19:01Z","timestamp":1758208741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Rb\u2010bFGF in Hair Transplantation: A Prospective and Comparative Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Jie","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Xijing Hospital, Fourth Military Medical University  Xi'an China"},{"name":"Department of Medicine Xi'an PLA Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglian","family":"An","sequence":"additional","affiliation":[{"name":"Emergency Department Jiangjin Hospital Affiliated to Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Xijing Hospital, Fourth Military Medical University  Xi'an 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