{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:20:56Z","timestamp":1764642056488,"version":"3.46.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Melasma is a chronic refractory pigmentation disorder. Kligman triple (KT) formula is the gold standard. A dermocosmetic (DC) serum containing vitamin B3 and 2\u2010mercaptonicotinyl glycine has been developed for melasma. This study assessed the benefits of DC serum compared to KT in melasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A randomized, single\u2010blind 6\u2010month study was conducted in women with melasma. Subjects were randomized to Group A (morning: serum; evening: cream, for 6\u2009months) or to Group B (1st 3\u2009months: morning: skin hydrating gel; evening: KT, followed by 3\u2009months of DC routine regimen); all subjects applied a sunscreen with an SPF 50+ twice daily. Assessments included MASI, mMASI, IGA, skin hydration, radiance and fine wrinkles, tolerance, and quality of life (QoL) using MELASQOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010one women aged 44\u2009\u00b1\u20096\u2009years of Phototypes III (30%) and IV (36%) were recruited. Both regimens significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) improved MASI after 3\u2009months. A clinically relevant difference in favor of KT was observed. Three months after the switch, both Group A (38.1%) and Group B (41.2%) provided a similar significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) percentage reduction of MASI score, with no between\u2010group difference. The mMASI and IGA showed similar results. QoL and skin hydration significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) improved in both groups after 6\u2009months. Skin radiance and fine wrinkles also improved. Global tolerance was better with the DC routine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both DC routine and KT significantly improved melasma after 3\u2009months of use. DC further improved melasma when replacing KT for 3 further months, with similar results when used alone for 6\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70476","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T09:57:20Z","timestamp":1759399040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Dermocosmetic Routine Containing Vitamin\n                    <scp>B3<\/scp>\n                    and 2\u2010Mercaptonicotinyl Glycine Significantly Improves Melasma After 3\u2009Months of Daily Use"],"prefix":"10.1111","volume":"24","author":[{"given":"Juliane","family":"Rocio","sequence":"first","affiliation":[{"name":"Institute of Dermatology &amp; Aesthetics of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Kovylkina","sequence":"additional","affiliation":[{"name":"Vichy Laboratoires International  Vichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Cestari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de Clinicas de Porto Alegre  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Fajgenbaum","family":"Feiges","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al LDB  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Fernandes","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al LDB  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Deloche\u2010Bensmaine","sequence":"additional","affiliation":[{"name":"Vichy Laboratoires International  Vichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Caberlotto","sequence":"additional","affiliation":[{"name":"Vichy Laboratoires International  Vichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"Thierry","family":"Passeron","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"C3M, INSERM U1065 Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00779-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4663"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03295.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84722"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2007.00415.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19677"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.115"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12736"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111525"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162541"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13844"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1914313"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00780-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02990-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13237483"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.051"},{"volume-title":"Skin Aging Atlas Volume 5: Photo\u2010Aging Face & Body","year":"2017","author":"Flament F.","key":"e_1_2_10_19_1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07591.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7428"},{"volume-title":"StatPearls","year":"2024","author":"Schwartz C.","key":"e_1_2_10_22_1"},{"issue":"11","key":"e_1_2_10_23_1","article-title":"Topical Hydroquinone for Hyperpigmentation: A Narrative Review","volume":"15","author":"Fabian I. 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