{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:14:35Z","timestamp":1776075275492,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Fractional ablative CO\n 2<\/jats:sub>\n lasers are widely used for skin rejuvenation but are associated with post\u2010procedural erythema, crusting, tenderness, and downtime. Carboxytherapy masks, a modality utilizing carbon dioxide, have been suggested to enhance healing and aesthetic outcomes post CO\n 2<\/jats:sub>\n laser treatment; however, controlled clinical data remain limited.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the efficacy and safety of a topical carboxytherapy mask in enhancing recovery, reducing adverse effects, and improving patient satisfaction following fractional ablative CO\n 2<\/jats:sub>\n laser treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Ten subjects (aged 45\u201370\u2009years, Fitzpatrick skin types I\u2013III) undergoing full\u2010face fractional CO\n 2<\/jats:sub>\n laser resurfacing were enrolled in this randomized pilot study. Participants were assigned to either the active arm (\n n<\/jats:italic>\n \u2009=\u20098, carboxytherapy mask was applied pre\u2010 and post\u2010procedure and at designated intervals for 14\u2009days) or placebo arm (\n n<\/jats:italic>\n \u2009=\u20092, bland moisturizer). Outcomes included blinded investigator assessments of erythema, edema, crusting, healing rate, pigmentation, and wrinkle severity at Days 28 and 84; patient\u2010reported diaries of discomfort and healing parameters; and self\u2010assessments of satisfaction and global aesthetic improvement.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The active group demonstrated reduced erythema during the first week (mean scores: Day 1, 3.1 vs. 3.5; Day 7, 0.6 vs. 1.0 for placebo). By Day 7, healing surface area averaged 97% in the active group with no crusting. At Day 28, the active group exhibited fewer fine and coarse lines (mean coarse line score 2 vs. 4 in placebo). At Day 84, coarse line reduction and abnormal pigmentation improvement favored the active group (0.75 vs. 1.5, respectively). Patient\u2010reported tenderness, burning, and crusting were consistently lower in the active group, with higher satisfaction and confidence scores at both Day 28 and 84. No adverse effects were reported.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this pilot study, the carboxytherapy mask enhanced post\u2010laser healing, reduced erythema and discomfort, and improved long\u2010term wrinkle and pigmentation outcomes compared to placebo. These findings support the adjunctive use of the carboxytherapy mask to improve recovery and patient satisfaction after ablative CO\n 2<\/jats:sub>\n laser resurfacing. Larger, controlled trials are warranted to confirm these results.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70481","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:28:51Z","timestamp":1760009331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Carboxytherapy Mask in Post\u2010Fractional Ablative Laser Recovery: A Randomized Pilot Trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Steven","family":"Dayan","sequence":"first","affiliation":[{"name":"DeNova Research Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Carvajal","sequence":"additional","affiliation":[{"name":"DeNova Research Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-7995","authenticated-orcid":false,"given":"Nimit","family":"Gandhi","sequence":"additional","affiliation":[{"name":"DeNova Research Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lander","family":"McGinn","sequence":"additional","affiliation":[{"name":"DeNova Research Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Cirrincione","sequence":"additional","affiliation":[{"name":"DeNova Research Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Sanchez\u2010Perez","sequence":"additional","affiliation":[{"name":"DeNova Research Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331979704800406"},{"key":"e_1_2_11_3_1","first-page":"205","article-title":"Carboinsufla\u00e7\u00e3o em \u00dalceras Cr\u00f4nicas dos Membros Inferiores","volume":"26","author":"Abramo A. C.","year":"2011","journal-title":"Revista Brasileira de Cirurgia Pl\u00e1stica (Impresso)"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"79","article-title":"Carboxytherapy: Effects on Microcirculation and Its Use in the Treatment of Severe Lymphedema","volume":"8","author":"Varlaro V.","year":"2007","journal-title":"Acta Phlebologica"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"201","article-title":"Increase in Collagen Turnover Induced by Intradermal Injection of Carbon Dioxide in Rats","volume":"7","author":"Ferreira J. C.","year":"2008","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_6_1","first-page":"144","volume-title":"Carboxytherapy: Practical Manual With Clinical Indications and Protocols","author":"Brandi C.","year":"2019"},{"issue":"5","key":"e_1_2_11_7_1","first-page":"72","article-title":"Carboxytherapy Is One of the Innovative Directions in Balneology","volume":"95","author":"Butatyan N. D.","year":"2018","journal-title":"Issues of Balneology, Physiotherapy, and Rehabilitative Physical Therapy"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15741"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2021.5856"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15860"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2003.12.011"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:18:53Z","timestamp":1764641933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/jocd.70481"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70481","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70481"}}