{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:17:28Z","timestamp":1768933048733,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze and evaluate the clinical effect of cosmetic debridement and suture combined with recombinant human epidermal growth factor (rhEGF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review of the literature was performed by searching China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journals, China Biomedicine, PubMed, Web of Science, and Cochrane Library. RevMan 5.4.1 software was used for statistical analysis. Heterogeneity among studies was assessed using the\n                      <jats:italic>Q<\/jats:italic>\n                      test (\n                      <jats:italic>p<\/jats:italic>\n                      value). Publication bias was evaluated via funnel plots, forest plots were generated, and the combined odds ratio (OR) was calculated using a fixed\u2010effects model or random\u2010effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combined therapy showed favorable clinical efficacy [OR\u2009=\u20096.62, 95% confidence interval (95% CI) (3.14\u201313.92),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001], shorter wound healing time [mean difference (MD)\u2009=\u2009\u22122.69, 95% CI (\u22123.10 to \u22122.29),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001], and improved scar outcomes (lower Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) scores) at 6\u2009months. Serum epidermal growth factor (EGF) levels were higher, while interleukin\u20106 (IL\u20106) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) levels were lower in the combined therapy group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aesthetic debridement and suture combined with rhEGF have a good clinical effect in the treatment of maxillofacial trauma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70491","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:21:03Z","timestamp":1761762063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Cosmetic Debridement and Suture With Recombinant Human\n                    <scp>EGF<\/scp>\n                    in Maxillofacial Trauma: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Yin","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery The First Affiliated Hospital of Dalian Medical University  Dalian Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-952X","authenticated-orcid":false,"given":"Yanhua","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University  Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12639"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30477"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275515"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12845"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.09.004"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"273","article-title":"Clinical Effects of Flaps or Myocutaneous Flaps Transplantation After Titanium Mesh\u2010Retaining Debridement in Repairing the Wounds With Exposed Titanium Mesh After Cranioplasty","volume":"40","author":"He L.","year":"2024","journal-title":"Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30420"},{"issue":"23","key":"e_1_2_10_9_1","first-page":"82","article-title":"Effects of Cosmetic Suture and Conventional Suture Combined With Recombinant Human Epidermal Growth Factor in the Treatment of Maxillofacial Trauma","volume":"4","author":"Zheng P.","year":"2019","journal-title":"Clinical Medical Research and Practice"},{"issue":"12","key":"e_1_2_10_10_1","first-page":"37","article-title":"Effect of Recombinant Human Epidermal Growth Factor on Oral and Maxillofacial Trauma","volume":"26","author":"Dong H. 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