{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:37:37Z","timestamp":1774499857395,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and safety of local injection of botulinum toxin type A in preventing hypertrophic scars after facial trauma and surgery using meta\u2010analysis and sequential experimental analysis methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Computer retrieval of randomized controlled trials on the prevention of facial scars with botulinum toxin type A from PubMed, EMbase, the Cochrane Library, CNKI, China Biomedical Literature Service System, Wanfang Database, and VIP Chinese Science and Technology Journal Full text Database up to February 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Twelve randomized controlled clinical trials were included, with a total of 644 patients; Type A botulinum toxin injection is superior to the control group in improving patient satisfaction [\n                      <jats:italic>RR\u2009=<\/jats:italic>\n                      \u20096.89; 95% CI (3.20, 14.85);\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.0001], Vancouver Scale score [\n                      <jats:italic>RR\u2009=<\/jats:italic>\n                      \u2009\u22121.40; 95% CI (\u22122.73, 0.08);\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.0001], visual analog score [\n                      <jats:italic>RR\u2009=<\/jats:italic>\n                      \u20091.41; 95% CI (0.26, 2.56);\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.02], scar width [\n                      <jats:italic>RR\u2009=<\/jats:italic>\n                      \u2009\u22120.14; 95% CI (\u22120.17, \u22120.10);\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.0001], and the difference is significant; The incidence of adverse events [\n                      <jats:italic>RR\u2009=<\/jats:italic>\n                      \u20090.38; 95% CI (0.18, 0.84);\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.02] and recurrence rate [\n                      <jats:italic>RR\u2009=<\/jats:italic>\n                      \u20090.17; 95% CI (0.04, 0.81);\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.03] were lower than those in the control group, and no serious adverse reactions occurred; Sensitivity analysis showed that the results were relatively robust, sequential analysis of the experiment showed that the benefits were conclusive, and Begg's and Egger's tests showed no publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Type A botulinum toxin injection has a certain therapeutic effect on hypertrophic scars without significant side effects. However, the accuracy and stability of its therapeutic effect still require more high\u2010quality research verification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70501","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:21:51Z","timestamp":1761711711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Botulinum Toxin Type A for Preventing Facial Trauma and Hypertrophic Scars: A Meta\u2010Analysis and Trial Sequential Analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Jie","family":"Lu","sequence":"first","affiliation":[{"name":"Medical Cosmetic Center Chengdu Second People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Cosmetic Center Chengdu Second People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Xie","sequence":"additional","affiliation":[{"name":"Medical Cosmetic Center Chengdu Second People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2354-4444","authenticated-orcid":false,"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chengdu Second People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12600"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01118.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000253"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0356-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03737-z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000011190"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-023-10113-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-023-02802-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2011000500004"},{"key":"e_1_2_11_11_1","first-page":"274","article-title":"A Novel lncRNA FPASL Regulates Fibroblast Proliferation via the PI3K\/AKT and MAPK Signaling Pathways in Hypertrophic Scar","volume":"55","author":"Ma F.","year":"2022","journal-title":"Acta Biochimica et Biophysica Sinica"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416652092"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307149"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0591-3"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417724150"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S86978"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2016.04.044"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410364677"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000416"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115690"},{"key":"e_1_2_11_22_1","first-page":"162","article-title":"Efficacy of Botulinum Toxin Type A in the Treatment of Keloid","volume":"2","author":"Huang L. 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