{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:21:04Z","timestamp":1764642064524,"version":"3.46.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013116","name":"Merz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013116","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Despite the widespread use of hyaluronic acid (HA)\u2010based fillers, most studies have focused on volumetric restoration rather than skin quality improvement. Objective imaging techniques, such as ultrasound strain elastography and corneometry, allow quantitative and qualitative assessment of treatment efficacy, filling an important gap in aesthetic dermatology research.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the safety and efficacy of treatment using the cohesive polydensified matrix hyaluronic acid with glycerol (CPM\u2010R, Belotero Revive; Anteis, Plan\u2010les\u2010Quates, Switzerland) delivered via microcannula for skin hydration, firmness, and elasticity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective cohort study was conducted, with eligible patients divided into 2 groups: patients who had received a single (group 1) or a two\u2010session treatment (group 2) of CPM\u2010R. Patients were evaluated at baseline and 30\u2009days after the final treatment by corneometry and ultrasound strain elastography. At the final follow\u2010up appointment (Day 30 (D30) for Group 1, Day 60 (D60) for Group 2), both the investigator and the patient assessed outcome efficacy using the 5\u2010point Global Aesthetic Improvement Scale (GAIS) and the Pain and Comfort Visual Analogue Scales (VAS).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 40 patients were included in the final analysis; mean age was 41.7\u2009years (range: 25\u201360), 85.0% were female (\n n<\/jats:italic>\n \u2009=\u200934\/40), and most patients had mild rosacea, acne\u2010prone, or dry skin. Of the 40 patients, 6 (16.0%) exhibited mild rosacea, and 12 (30.0%) had acne\u2010prone skin. No patients withdrew from the study. Hydration levels, as assessed by corneometry, significantly improved following treatment with CPM\u2010R by an average of 14.9% after a single treatment and 16.6% after two treatments spaced four weeks apart (\n p<\/jats:italic>\n \u2009<\u20090.001). The investigator and patient evaluations of facial appearance were either \u201cmuch improved\u201d or \u201cvery much improved\u201d in all patients who underwent a single\u2010treatment or two\u2010treatment protocol. No serious adverse events were reported. Minor and transient side effects (e.g., local mild erythema and ecchymosis) were reported in 15.0% (\n n<\/jats:italic>\n \u2009=\u20096\/40) and 7.5% (\n n<\/jats:italic>\n \u2009=\u20093\/40) of cases, respectively, and resolved spontaneously within 24\u201372\u2009h. Patients reported minimal discomfort, with 75.0% (\n n<\/jats:italic>\n \u2009=\u200930\/40) of the patients reporting an average VAS pain score of 1 (out of 10).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study demonstrated that the use of CPM\u2010R delivered through retro\u2010linear and fanning techniques with a microcannula is an innovative, effective, safe, and well\u2010tolerated intervention for improving skin hydration and overall dermal quality in patients with mild to moderate signs of aging.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70509","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:50:42Z","timestamp":1760701842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bio\u2010Revitalizing\n SkinGlow<\/scp>\n : Assessing the Efficacy of Microcannula\u2010Assisted Treatment With Cohesive Polydensified Matrix Hyaluronic Acid With Glycerol (Belotero Revive) Through Ultrasound Elastography and Corneometry"],"prefix":"10.1111","volume":"24","author":[{"given":"Suhail","family":"Luna","sequence":"first","affiliation":[{"name":"Xiluet Medical Private Practice Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S239367"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210296"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S209256"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.77069"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal\u2010D\u201017\u201000088"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"177","article-title":"Overview of Skin Aging and Photoaging","volume":"20","author":"Helfrich Y. R.","year":"2008","journal-title":"Dermatology Nursing"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0356"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.3.282"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000204759.76865.39"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S106551"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354384"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13167"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15157"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:19:35Z","timestamp":1764641975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/jocd.70509"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70509","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70509"}}