{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:07:17Z","timestamp":1792271237997,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014565","name":"Bausch Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Energy\u2010based devices, such as lasers, provide effective treatments for skin resurfacing. Ablative fractional lasers have a higher risk of adverse events (AEs), like scarring and postinflammatory hyperpigmentation, particularly in patients with darker skin types, than non\u2010ablative fractional lasers. The 1440\u2010 and 1927\u2010nm non\u2010ablative fractional diode laser (NFDL) system is indicated for use in dermatological procedures requiring the coagulation of soft tissue and for general skin resurfacing procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To help inform clinical decision\u2010making about the dual 1440\/1927\u2010nm NFDL system, particularly for treating patients with diverse skin types who require safe and effective resurfacing treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PubMed search of literature was conducted to review safety and tolerability outcomes from clinical studies of 1440\u2010 and 1927\u2010nm NFDL treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Expected skin reactions, including erythema, edema, and crusting, were mild to moderate and self\u2010limited for concurrent and individual use of the 1440\u2010 and 1927\u2010nm handpieces. Mild discomfort and heat sensation, which\u00a0were also expected, indicated that treatment was well tolerated. Safety was also demonstrated in patients with skin of color, with no serious AEs. Levels of patient satisfaction were high.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The dual 1440\/1927\u2010nm NFDL system is a safe and well\u2010tolerated option for resurfacing of diverse skin types with minimal postprocedural downtime and reduced risk of AEs relative to ablative lasers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70523","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:24:52Z","timestamp":1763018692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Tolerability of the 1440\u2010 and 1927\u2010nm Non\u2010Ablative Fractional Diode Laser System for Skin Resurfacing: A Review of Current Literature"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9803-8276","authenticated-orcid":false,"given":"Roy G.","family":"Geronemus","sequence":"first","affiliation":[{"name":"New York University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-2745","authenticated-orcid":false,"given":"Jordan V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of Pennsylvania  Devon Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-2280","authenticated-orcid":false,"given":"Abby A.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Bausch Health Companies Inc  Bridgewater New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-7807","authenticated-orcid":false,"given":"Ellen S.","family":"Marmur","sequence":"additional","affiliation":[{"name":"Marmur Medical  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel D.","family":"Polder","sequence":"additional","affiliation":[{"name":"Dallas Center for Dermatology and Aesthetics  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1195272"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003397"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101329413"},{"issue":"6","key":"e_1_2_10_5_1","first-page":"51","article-title":"Nonablative Fractional Laser Resurfacing in Skin of Color: Evidence\u2010Based Review","volume":"10","author":"Kaushik S. B.","year":"2017","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"8","key":"e_1_2_10_6_1","first-page":"s3","article-title":"The 1440 nm and 1927 nm Nonablative Fractional Diode Laser: Current Trends and Future Directions","volume":"19","author":"Friedman P. M.","year":"2020","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_10_7_1","first-page":"85","volume-title":"Procedures in Cosmetic Dermatology: Lasers, Lights, and Energy Devices","author":"Watchmaker J.","year":"2023"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20254"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2241745"},{"key":"e_1_2_10_11_1","unstructured":"E. L.Elford S. K.Struck andV. P.Bedi \u201cLow Dose 1440 nm Laser Treatment Induces Collagen Deposition and Pigment Removal \u201dPresented at: Orlando Dermatology Aesthetic and Clinical Conference; January 13\u201015 2012; Orlando FL."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16514"},{"key":"e_1_2_10_13_1","volume-title":"CLEAR + BRILLIANT Laser System. User Manual","year":"2020"},{"key":"e_1_2_10_14_1","unstructured":"E. L.ElfordandV. P.Bedi \u201cEnhanced Skin Permeability of Ascorbic Acid After CLEAR + BRILLIANT Perm\u00e9a Laser Treatment \u201dPresented at: American Society for Laser Medicine and Surgery Annual Conference; April 18\u201322 2012; Kissimmee FL."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004283"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23767"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004379"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.041"},{"issue":"11","key":"e_1_2_10_19_1","first-page":"1262","article-title":"Evaluation of a Low Energy, Low Density, Non\u2010Ablative Fractional 1927 nm Wavelength Laser for Facial Skin Resurfacing","volume":"14","author":"Brauer J. A.","year":"2015","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_10_20_1","unstructured":"E. L.Elford A.Loncaric T.Kalista et\u00a0al. \u201cTreatment of Photodamaged Skin Using Fractional Non\u2010Ablative Laser in Combination With Topical Antioxidants \u201dPresented at: American Society for Laser Medicine and Surgery Annual Conference; April 18\u201022 2012; Kissimmee FL."},{"key":"e_1_2_10_21_1","first-page":"21","article-title":"Treatment With the Clear + Brilliant Permea Laser System: Combined Experience of 9 Laser Centres","volume":"19","author":"Polder K. 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