{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:07:16Z","timestamp":1790885236987,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hair graying is an age\u2010associated condition primarily caused by the depletion and dysfunction of melanocyte stem cells within hair follicles. Emerging regenerative strategies, including exosome\u2010based therapies, offer the potential to restore pigmentation by targeting underlying cellular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical outcomes and correlates of hair repigmentation following exosome\u2010based therapy in individuals with gray hair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional observational study enrolled 10 patients with visible gray or white hair who were treated with rose stem cell\u2010derived exosomes (RSCEs) using various procedures. Gray hair repigmentation outcomes were assessed using a standardized scale. Statistical correlations between clinical variables and treatment responses were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A mean of 4.6\u2009\u00b1\u20091.3 treatment sessions was performed. Repigmentation was observed after an average of 2.4\u2009\u00b1\u20090.7 sessions and was maintained for 4.7\u2009\u00b1\u20091.9\u2009months. The various treatment modalities also demonstrated efficacy in both hair regrowth and hair repigmentation. The mean outcome score was 2.8\u2009\u00b1\u20090.78, with 60% achieving a higher\u2010grade response (\u2265\u200950% improvement). Shorter duration of graying (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0363), presence of androgenetic alopecia (AGA) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0332), and moderate baseline severity (Stage 2) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0133) were significantly associated with better outcomes. No adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exosome\u2010based therapy appears to be a safe and promising approach for inducing hair repigmentation in individuals with gray hair using various treatment modalities. Factors such as the presence of AGA, shorter duration of graying, and moderate baseline severity may predict a better response. Larger, controlled studies are warranted to validate these findings and help standardize treatment protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70526","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:33:43Z","timestamp":1762518823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross\u2010Sectional Observational Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2982","authenticated-orcid":false,"given":"Suparuj","family":"Lueangarun","sequence":"first","affiliation":[{"name":"Department of Aesthetic Medicine, College of Integrative Medicine Dhurakij Pundit University  Bangkok Thailand"},{"name":"Division of Dermatology DeMed Clinic Center  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-8284","authenticated-orcid":false,"given":"Patrick Po\u2010Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Huang PH Dermatology and Aesthetics  Kaohsiung Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9767-2625","authenticated-orcid":false,"given":"Wan\u2010Yi","family":"Chou","sequence":"additional","affiliation":[{"name":"Sincere Dermatology Clinic  Taipei City Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Theodorakopoulou","sequence":"additional","affiliation":[{"name":"Pretty You Dermatology Clinic  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Lemes","sequence":"additional","affiliation":[{"name":"DL Dermatology and Laser Clinic  Rio de Janeiro 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