{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:05:29Z","timestamp":1787753129147,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polynucleotides (PN) are innovative polymers that improve skin hydration and elasticity, serving as alternatives to traditional dermal fillers. Medical devices based on PN High Purification Technology (PN HPT) represent a new generation of injectable products designed to restore hydration, elasticity, and overall tissue quality. PN HPT is known for its clinical versatility and excellent tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the real\u2010world performance and safety of Plinest (40\u2009mg\/2\u2009mL of PN HPT in a 2\u2009mL pre\u2010filled syringe), a CE\u2010marked class III medical device for skin rejuvenation of the face, neck, and d\u00e9collet\u00e9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational clinical data collection involved 66 adult patients, each of whom could receive treatment in up to three areas (face, neck, d\u00e9collet\u00e9). Patients underwent three sessions of intradermal PN HPT injections. A total of 106 questionnaires were collected: 47 for the face, 33 for the neck, and 26 for the d\u00e9collet\u00e9. Performance was evaluated using the Global Clinical Improvement Scale (GCI\u2010S) and Global Aesthetic Improvement Scale (GAIS). Safety was monitored through spontaneous adverse event (AE) reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinician\u2010reported outcomes showed visible improvement in 100% of facial treatments, with 53.5% rated as \u201cmarked\u201d or \u201cexcellent.\u201d In the neck and d\u00e9collet\u00e9 areas, moderate to significant improvements were observed in over 93% and 88% of cases, respectively. Patient satisfaction ranged from 97% to 100%. No serious AEs occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PN HPT demonstrated a favorable tolerability and performance profile in real\u2010life aesthetic practice, supporting its role in improving skin quality and reducing signs of aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70532","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:00:02Z","timestamp":1767420002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Real\u2010Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1024-3556","authenticated-orcid":false,"given":"Lanza","family":"Eliana","sequence":"first","affiliation":[{"name":"Estederm  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perna","family":"Anna","sequence":"additional","affiliation":[{"name":"Studio Perna  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bizzarri","family":"Stefania","sequence":"additional","affiliation":[{"name":"Villa Alba  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santoro","family":"Concetta","sequence":"additional","affiliation":[{"name":"Ini villa alba centro storico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0152-4187","authenticated-orcid":false,"given":"Cerutti","family":"Luisa","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Sapienza Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dybala","family":"Agnieszka","sequence":"additional","affiliation":[{"name":"Centro Medico Polispecialistico Analysis  Terracina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-9269","authenticated-orcid":false,"given":"Brunoro","family":"Andrea","sequence":"additional","affiliation":[{"name":"Beauty Formula Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boffi","family":"Laura","sequence":"additional","affiliation":[{"name":"Bovisio Polimedica Bovisio Masciago  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prussia","family":"Carolina","sequence":"additional","affiliation":[{"name":"Medical Statistics Consultant  Locarno Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4772-2789","authenticated-orcid":false,"given":"Saretta","family":"Simone","sequence":"additional","affiliation":[{"name":"Medicina Estetica Zazzaron  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16688"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"47","article-title":"Look Better, Feel Better, Live Better? The Impact of Minimally Invasive Aesthetic Procedures on Satisfaction With Appearance and Psychosocial Wellbeing","volume":"15","author":"Hoffman L.","year":"2022","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11020049"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"1","article-title":"PN HPT and Striae Albae\u2014Exploratory Interim Analysis of a Randomised Prospective Study","volume":"5","author":"Bartoletti E.","year":"2023","journal-title":"Surgical Research"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15064"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.29011\/2575\u20108268.100224"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab125"},{"key":"e_1_2_11_9_1","unstructured":"S.Mastelli \u201cInstrumental Evaluation of the Skin Hydration Efficacy of Three Products \u201d(2022)."},{"key":"e_1_2_11_10_1","first-page":"27","article-title":"Long Chain Polynucleotides Gel and Skin Biorevitalization","volume":"3","author":"Cavallini M.","year":"2007","journal-title":"Journal of Plastic Dermatology"},{"key":"e_1_2_11_11_1","volume-title":"Instructions for Use","author":"Plinest","year":"2023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2021.03.020"},{"issue":"7","key":"e_1_2_11_13_1","first-page":"28","article-title":"The Clinical Global Impressions Scale: Applying a Research Tool in Clinical Practice","volume":"4","author":"Busner J.","year":"2007","journal-title":"Psychiatry"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524\u20104725.2003.29150.x"},{"issue":"140","key":"e_1_2_11_15_1","first-page":"55","article-title":"A Technique for the Measurement of Attitudes","volume":"22","author":"Likert R.","year":"1932","journal-title":"Archives of Psychology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.124.6.869"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2019.02.013"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13679"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010024\u201003088\u20109"},{"issue":"2","key":"e_1_2_11_20_1","first-page":"103","article-title":"Tightening Upper Arms Skin Laxity With Intradermal Polynucleotides Gel Biorevitalization","volume":"40","author":"D'Aloiso M. 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