{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:19:05Z","timestamp":1781212745124,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The exact mechanism underlying hypertrophic scar (HS) remains elusive at present.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n This study aimed to investigate the potential regulatory mechanism of microRNA\u2010431\u20105p in HS.<\/jats:p>\n <\/jats:sec>\n \n Patients\/Methods<\/jats:title>\n \n 100 HS patients were recruited in this study. The relative expression of miR\u2010431\u20105p,\n ZEB1<\/jats:italic>\n , and\n \u03b1\u2010SMA<\/jats:italic>\n was quantified using RT\u2010qPCR. Cell proliferation was assessed via the CCK\u20108 assay. Cell migration was evaluated using the Transwell. Cell apoptosis was determined by flow cytometry. Inflammatory factors' levels were measured through ELISA (Enzyme\u2010Linked Immunosorbent Assay). The targeting regulatory relationship was confirmed by the dual\u2010luciferase assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n miR\u2010431\u20105p was significantly reduced in HS tissues. Overexpression of miR\u2010431\u20105p markedly suppressed cell proliferation and migration, promoted apoptosis, downregulated the levels of\n IL\u20101\u03b2<\/jats:italic>\n (\n Interleukin\u20101\u03b2<\/jats:italic>\n ) and\n IL\u20106<\/jats:italic>\n (\n Interleukin\u20106<\/jats:italic>\n ), and inhibited\n \u03b1\u2010SMA<\/jats:italic>\n expression. Moreover,\n ZEB1<\/jats:italic>\n was highly expressed in HS tissues, and miR\u2010431\u20105p negatively regulated\n ZEB1<\/jats:italic>\n . Further investigation revealed that overexpression of\n ZEB1<\/jats:italic>\n could partially reverse the regulatory effects of miR\u2010431\u20105p on cellular behavior.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The miR\u2010431\u20105p\/\n ZEB1<\/jats:italic>\n axis was involved in the regulation of HS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70533","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T19:23:50Z","timestamp":1763493830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overexpression of\n miR<\/scp>\n \u2010431\u20105p Inhibits the Development of Hypertrophic Scars by Negatively Regulating the Expression of\n \n ZEB1<\/i>\n <\/scp>"],"prefix":"10.1111","volume":"24","author":[{"given":"Yaqing","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Services Department Shanghai Changzheng Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Tongde Hospital of Zhejiang Province Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0744-3773","authenticated-orcid":false,"given":"Suwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tongde Hospital of Zhejiang Province Hangzhou 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