{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:44:17Z","timestamp":1784825057033,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010NR070251"],"award-info":[{"award-number":["RS\u20102022\u2010NR070251"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Sensitive skin is often characterized by increased sensitivity to environmental and cosmetic stimuli, leading to pruritus and pain. Current treatments remain inadequate, leaving many affected individuals in discomfort. Troxerutin, a TRPV1\u2010inhibiting material, has shown potential in alleviating these symptoms by improving skin barrier function.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study evaluates the efficacy of a topical formulation containing troxerutin in reducing skin sensitivity, improving hydration, and enhancing the quality of life in individuals with sensitive skin.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Adult participants over 20\u2009years old with clinically diagnosed sensitive skin applied a troxerutin\u2010containing moisturizer twice daily for 8\u2009weeks. The effects were assessed using transepidermal water loss (TEWL), stratum corneum hydration (SCH), Sensitive Scale\u201010 (SS\u201010), and Dermatology Life Quality Index (DLQI). Measurements were taken at baseline, 2, 4, and 8\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty adult participants who were clinically diagnosed with sensitive skin were registered. Statistically significant reductions in TEWL were observed at 2\u2009weeks (\n p<\/jats:italic>\n \u2009=\u20090.047) and 4\u2009weeks (\n p<\/jats:italic>\n \u2009=\u20090.021), indicating an improvement in skin barrier function. SCH significantly increased after 2 and 4\u2009weeks (\n p<\/jats:italic>\n \u2009=\u20090.007,\n p<\/jats:italic>\n \u2009=\u20090.002). SS\u201010 scores improved markedly, from 64.17\u2009\u00b1\u200912.96 at baseline to 39.84\u2009\u00b1\u200917.00 at 8\u2009weeks (\n p<\/jats:italic>\n \u2009<\u20090.001), suggesting decreased skin sensitivity. The DLQI score improved from 18.60\u2009\u00b1\u20095.00 to 8.50\u2009\u00b1\u20095.10 (\n p<\/jats:italic>\n \u2009=\u20090.000), highlighting enhanced quality of life. Additionally, regional facial erythema\u2014most notably in the cheeks and nose\u2014was significantly reduced after 4\u2009weeks of treatment, indicating a beneficial effect on localized vascular reactivity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Troxerutin significantly reduces pruritus and pain in individuals with sensitive skin and enhances skin barrier function and hydration, ultimately improving overall skin comfort and patient satisfaction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70541","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:42:57Z","timestamp":1762951377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Pruritic and Analgesic Effects of a Topical Formulation Containing Troxerutin: A Pilot Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-199X","authenticated-orcid":false,"given":"Ji Young","family":"Um","sequence":"first","affiliation":[{"name":"Department of Dermatology Hallym University Kangnam Sacred Heart Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Gyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Computer Science Kwangwoon University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"LG Science Park R&D Center LG Household & Healthcare (LG H&H) Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-7505","authenticated-orcid":false,"given":"Han Bi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hallym University Kangnam Sacred Heart Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-4290","authenticated-orcid":false,"given":"So Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hallym University Kangnam Sacred Heart Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Yoo","sequence":"additional","affiliation":[{"name":"LG Science Park R&D Center LG Household & Healthcare (LG H&H) Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeeun","family":"Cho","sequence":"additional","affiliation":[{"name":"LG Science Park R&D Center LG Household & Healthcare (LG H&H) Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulhee","family":"Na","sequence":"additional","affiliation":[{"name":"LG Science Park R&D Center LG Household & Healthcare (LG H&H) Seoul 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Kangnam Sacred Heart Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0008","authenticated-orcid":false,"given":"Hye One","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hallym University Kangnam Sacred Heart Hospital Seoul 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