{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T20:46:44Z","timestamp":1766436404304,"version":"3.48.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dry skin is a prevalent dermatological concern influenced by environmental factors and characterized by compromised skin barrier integrity. In addition to this, skin microbiota is involved and plays a crucial role in maintaining microbial flora balance. This study aims to investigate dry skin condition and microbiota then the efficacy of a novel skincare formulation (Nourish 3\u2010Biotic Rich Serum) containing prebiotics, probiotics and postbiotics in addressing dry skin symptoms and rebalancing skin microbiota. They are mainly microorganism lysate, together with fermented substances such as oligosaccharides, enzymes, and peptides, that support and provide nourishment to bacteria that live on the skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Serum formula and serum placebo were tested in a single\u2010blind study in which 20 female volunteers aged 28\u201365 with dry skin were enrolled. Several skin biophysical parameters related to skin barrier condition (\n                      <jats:italic>stratum corneum<\/jats:italic>\n                      water content, transepidermal water loss (TEWL), protein content), mechanical properties (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      ,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      ) and topographic appearance (skin roughness) and skin microbiota analysis were monitored over 30\u2009days of daily application of the products in a split\u2010face protocol. To better understand the results, the selected panel was then divided into two groups based on different ages: younger (&lt;\u200950\u2009years) and older (&gt;\u200950\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>\n                      This study highlighted that the product has proven to have a moisturizing action, exerts a cellular renewal action, improves skin firmness and elasticity, and reduces skin roughness. For microbial analysis, the main evidence is that both the placebo and the product help restore the skin microbiota but only the product increased the quantity of\n                      <jats:italic>Cutibacterium acnes<\/jats:italic>\n                      (one of the primary commensal bacteria of the skin) and was able to decrease the abundance of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pseudomonas koreensis<\/jats:italic>\n                      <\/jats:styled-content>\n                      usually associated with dry and rosacea skin with beneficial effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70546","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:55:55Z","timestamp":1763801755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Microbial and Biophysical Aspects of Dry Skin: In\u00a0Vivo Test of a Novel Skincare Formulation"],"prefix":"10.1111","volume":"24","author":[{"given":"Camilla","family":"D'Antonio","sequence":"first","affiliation":[{"name":"Scientific Department Medspa Srl  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizia Lo","family":"Bosco","sequence":"additional","affiliation":[{"name":"Scientific Department Medspa Srl  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Gentili","sequence":"additional","affiliation":[{"name":"Scientific Department Medspa Srl  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Scientific Department Medspa Srl  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"DeMartini","sequence":"additional","affiliation":[{"name":"Etichub s.r.l., Academic Spin\u2010Off University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Condr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Drug Sciences University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-8534","authenticated-orcid":false,"given":"Paola","family":"Perugini","sequence":"additional","affiliation":[{"name":"Etichub s.r.l., Academic Spin\u2010Off University of Pavia  Pavia Italy"},{"name":"Department of Drug Sciences University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467\u20102494.2000.00001.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311\u2010023\u201001649\u20104"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19745"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102397"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2017.035"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16171"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1322205"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071\u2010200304110\u201000005"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2018.03.012"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102523"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113071"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260144"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16155"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16212"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105\u2010009\u20101759\u20104"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13540"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/app14031183"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2009.00932.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030966"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010020\u201000546\u20108"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02945\u201019"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010023\u201000842\u2010z"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275\u2010024\u201000128\u2010x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2013.0040"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124550"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10030091"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030684"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030628"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13040791"}],"container-title":["Journal 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