{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T02:36:16Z","timestamp":1788662176022,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyaluronic acid based skinboosters present a low rheological profile that allows for even distribution throughout the dermis and focuses on improving skin's overall quality. Scientific efforts are ongoing with the aim of developing optimal skinboosters that meet specific clinical requirements and satisfactory overall results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Assess clinically the efficacy and safety of a newly developed skinbooster known as BtHLINE for face, neck and d\u00e9collet\u00e9 rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this prospective and single\u2010centre clinical trial, 81 volunteers with signs of cutaneous aging received three intradermal injections of BtHLINE every 3\u2009weeks and were followed up for 15\u2009days, 3\u2009months and 6\u2009months. Efficacy evaluation included the Multifactorial Aesthetic Scale (MAS), the Global Aesthetic Improvement Scale (GAIS) and the Likert's patient satisfaction questionnaire. Biometric parameters were also assessed over the facial area using specific aesthetic instrumentation such as Visioscan, Cutometer, Moisturemap and Visioface tools. Adverse events related to the treatment were registered throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MAS score reached a statistically significant improvement at each time point for every treated area. Accordingly, GAIS and patient satisfaction surveys showed a clinically noticeable percentage of responders at the end of the follow\u2010up. The biometric analysis revealed that BtHLINE promoted a rapid and significant improvement that was maintained during the follow\u2010up period in terms of cutaneous uniformity, viscoelasticity, flexibility, firmness, water content, hydration, wrinkle depth, surface irregularities, scaling and smoothness. Adverse events were slight and considered as usual among skinboosters and were resolved within a few days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that BtHLINE is safe and effective for the promotion of skin rejuvenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70547","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:39:11Z","timestamp":1763357951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Biometric Assessment of a Hyaluronic Acid\u2010Based Skin Booster for Face, Neck and D\u00e9collet\u00e9 Rejuvenation: A Prospective Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3102-4783","authenticated-orcid":false,"given":"A.","family":"Pino","sequence":"first","affiliation":[{"name":"i+Med S. Coop.  Vitoria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4273-7918","authenticated-orcid":false,"given":"J.","family":"Torrecilla","sequence":"additional","affiliation":[{"name":"i+Med S. Coop.  Vitoria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Alonso","sequence":"additional","affiliation":[{"name":"i+Med S. Coop.  Vitoria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tovito","sequence":"additional","affiliation":[{"name":"Complutense Medical Centre (Virtus Group)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"i+Med S. Coop.  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