{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T20:46:33Z","timestamp":1766436393728,"version":"3.48.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenic alopecia (AGA) is a common condition characterized by progressive hair loss influenced by dihydrotestosterone (DHT). While oral dutasteride has shown efficacy in treating AGA, concerns about systemic side effects have prompted interest in localized treatments such as intralesional administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This systematic review evaluates the effectiveness and safety of intralesional dutasteride for treating AGA in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, we conducted a comprehensive search of multiple databases for studies involving adults (\u2265\u200918\u2009years) with AGA treated with intralesional dutasteride. Eligible studies included randomized controlled trials, non\u2010randomized studies, cohort studies, and observational studies. Exclusion criteria were animal studies, duplicate publications, and studies lacking relevant outcome data. The primary outcomes were improvements in hair density, hair thickness, and photographic evidence of hair growth. Secondary outcomes assessed safety, including local and systemic adverse events. Data extraction and quality assessment were independently performed by two reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Included studies consistently reported improvements in hair density and thickness following intralesional dutasteride treatment, with photographic evidence supporting visual improvement. Treatment was generally well tolerated, with minimal adverse events such as mild scalp irritation and no significant systemic effects reported. However, the studies varied in methodology, sample size, and follow\u2010up duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intralesional dutasteride appears to be a promising treatment option for AGA, offering localized efficacy with a favorable safety profile. Nonetheless, the current evidence is limited by heterogeneity and a lack of large\u2010scale, high\u2010quality trials. Further standardized research is needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70560","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:19:24Z","timestamp":1765358364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and Safety of Intralesional Dutasteride in Patients With Androgenic Alopecia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-7852","authenticated-orcid":false,"given":"Abdullah","family":"Almeziny","sequence":"first","affiliation":[{"name":"College of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-3107","authenticated-orcid":false,"given":"Asail","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Dermatology Department King Fahad Hospital  Albaha Saudi\u00a0Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alhanoof","family":"Alajlan","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah A.","family":"Almarhab","sequence":"additional","affiliation":[{"name":"College of Medicine Umm Al\u2010Qura University  Al\u2010Qunfudhah Saudi\u00a0Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areen E.","family":"Almatham","sequence":"additional","affiliation":[{"name":"Qassim University  Buraydah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esraa A.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"King Salman Medical City  Medinah Saudi\u00a0Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"Altalhab","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Ibrahim","family":"Alkhalifah","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"},{"name":"Prince Sultan Military Medical City  Riyadh Saudi 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