{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:04:50Z","timestamp":1793066690837,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thermal injuries caused by laser incisions in soft tissue can delay wound healing by triggering inflammation and tissue damage. Plant\u2010derived exosomes have recently gained attention as innovative biological agents with promising regenerative capabilities for soft tissue repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the effectiveness of injecting three commercial plant\u2010based exosome products: Exoline, Glow, and Elysee in enhancing the healing process of laser\u2010induced skin wounds in a rabbit model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and twenty adult male New Zealand rabbits were randomized into four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930 each): untreated control, Exoline, Glow, and Elysee. Full\u2010thickness 1\u2009\u00d7\u20091\u2009cm laser wounds were created on the ventral aspect of the right ear. Exosome\u2010treated groups received 0.1\u2009mL injections into the wound bed and margins immediately after injury. Animals were sacrificed at baseline (Day 0) to confirm comparable wound conditions across groups, and subsequently at Day 7 and Day 14. Wound healing was assessed grossly and histologically using hematoxylin and eosin, Masson's trichrome (for collagen fiber deposition), and CD31 immunohistochemistry (for angiogenesis). Quantitative scoring was performed by blinded observers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinically, all wounds achieved apparent closure by Day 14; however, histological assessment revealed persistent differences in tissue organization and angiogenesis between groups. At Day 7, Glow induced the highest collagen deposition, followed by Elysee and Exoline, whereas Exoline elicited the strongest angiogenic response, followed by Elysee and Glow. By Day 14, Glow maintained the lead in collagen maturation, followed by Exoline and Elysee, while Exoline remained most effective for angiogenesis, followed by Elysee and Glow. All exosome\u2010treated groups significantly outperformed controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plant\u2010derived exosomes enhance cutaneous wound repair with formulation\u2010specific benefits. Glow optimized early and late collagen deposition, Exoline promoted angiogenesis, and Elysee contributed to intermediate angiogenic effects. These findings support the potential for tailored exosome\u2010based therapies in regenerative dermatology. These preliminary results in a rabbit model warrant further investigation in long\u2010term studies and human clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70561","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:09:31Z","timestamp":1763978971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Regenerative Potential of Various Plant\u2010Derived Exosome Injections in Laser\u2010Induced Skin Wound Healing in a Rabbit Model"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-3736","authenticated-orcid":false,"given":"Noury","family":"Adel","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery Specialist Private Practice  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Kolenda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Thulesen","sequence":"additional","affiliation":[{"name":"Private Practice  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Private Practice  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Llano","sequence":"additional","affiliation":[{"name":"Private Practice  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Vega","family":"Thulesen","sequence":"additional","affiliation":[{"name":"Eye\u00a0Department Roskilde University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jo","sequence":"additional","affiliation":[{"name":"Orsayun Clinic  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Braun","sequence":"additional","affiliation":[{"name":"Private Practice  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa Ragaei","family":"Hassan","sequence":"additional","affiliation":[{"name":"Saxony Egypt University for Applied Sciences and Technology  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403025041840"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598025019459"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2024.12.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2024.0082"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.70589"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13232"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/20595131251316791"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2895"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15010014"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202403085RR"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16761"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S506221"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s4136802500370y"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8872"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.113650"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346025019550"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c12480"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15030394"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157087"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006949"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15193"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500042R"},{"issue":"4","key":"e_1_2_12_24_1","first-page":"481","article-title":"Comparison of Ketamine Xylazine and Ketamine Dexmedetomidine Anesthesia and Intraperitoneal Tolerance in Rats","volume":"52","author":"Wellington D.","year":"2013","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20217"},{"issue":"3","key":"e_1_2_12_26_1","first-page":"79","article-title":"Metody \u00e9vtanazii \u00e9ksperimental'nykh zhivotnykh\u2014\u00e9tika, \u00e9stetika, bezopasnost' personala [Methods for the Euthanasia of Experimental Animals\u2014The Ethics, Esthetics and Personnel Safety]","volume":"31","author":"Kopaladze R. A.","year":"2000","journal-title":"Uspekhi Fiziologicheskikh Nauk"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s1159601615787"},{"key":"e_1_2_12_28_1","volume-title":"Bancroft's Theory and Practice of Histological Techniques","author":"Suvarna S. K.","year":"2019"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_84_18"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758835920928635"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S548986"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17903"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083827"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123813"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16709"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12060574"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17982"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1626066"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:28:01Z","timestamp":1766428081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jocd.70561"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70561","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70561"}}