{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T20:46:27Z","timestamp":1766436387010,"version":"3.48.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate topical Replenishing Lip Filler\u2010Tiered Release Vesicles (RLF\u2010TRV) in filler\u2010na\u00efve and previously\u2010augmented lips.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two single\u2010center trials evaluated efficacy and tolerability of RLF\u2010TRV Serum. Study 1 included filler\u2010na\u00efve subjects or those without lip filler for 12\u2009months. Study 2 enrolled subjects with prior HA lip augmentation (3\u20139\u2009months earlier) in a double\u2010blind, placebo\u2010controlled design. Participants applied RLF\u2010TRV or placebo twice daily for 3\u2009weeks, followed by a 2\u2010week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I\u2010GAIS, S\u2010GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RLF\u2010TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were \u201cImproved\u201d on I\u2010GAIS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and 81% were \u201cMuch\u2010Improved\u201d on S\u2010GAIS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In Study 2, 88% of treated participants were \u201cImproved\u201d on both I\u2010GAIS and S\u2010GAIS. RLF\u2010TRV was well tolerated, with no recorded adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RLF\u2010TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70563","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:50:58Z","timestamp":1763801458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Tolerability of a Topical Peptide\u2010Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation"],"prefix":"10.1111","volume":"24","author":[{"given":"Amir","family":"Moradi","sequence":"first","affiliation":[{"name":"Moradi MD  Vista California USA"},{"name":"Pacific Clinical Innovations  Vista California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Jacob","sequence":"additional","affiliation":[{"name":"Chicago Cosmetic Surgery and Dermatology  Chicago Illinois USA"},{"name":"Northwestern Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Tao","sequence":"additional","affiliation":[{"name":"Modern Skin Dermatology  Hinsdale Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Love","sequence":"additional","affiliation":[{"name":"Ourself  Carlsbad California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Osborne","sequence":"additional","affiliation":[{"name":"Ourself  Carlsbad California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9210-5212","authenticated-orcid":false,"given":"Tina","family":"Fleck","sequence":"additional","affiliation":[{"name":"Ourself  Carlsbad California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392\u2010100X\u20101511"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102494.2008.00459.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2003.05741.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12692"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005190"},{"key":"e_1_2_12_7_1","first-page":"612","volume-title":"Harry's Cosmeticology","author":"Smejkalova D.","year":"2015"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.21923"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004504"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2020.10.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab358"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.681028"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003642200"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82153-6"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.044"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071346"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1280100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29174174"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060955"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010009\u20100932\u2010z"},{"key":"e_1_2_12_21_1","unstructured":"M. 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L.Park \u201cHyaluronidase Inhibitor Containing Poly\u2010Gamma\u2010Glutamic Acid as an Effective Component\u201d(2008) US Patent Application 2008\/0247986 A1."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.10.36849\/JDD.2020.5139"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524\u20104725.2003.29150.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347\u20109264.2019.73"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363380"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010070"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:27:45Z","timestamp":1766428065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jocd.70563"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70563","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"2025-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70563"}}