{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:20:19Z","timestamp":1770596419375,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Hair loss is a global concern for both men and women.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n This study assessed the efficacy and safety of a proprietary extract of bioactive fatty acids from saw palmetto for treating self\u2010perceived thinning hair in healthy adult male and female subjects.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this 6\u2010month, randomized, double\u2010blind, placebo\u2010controlled study, subjects were randomized to receive active treatment (\n n<\/jats:italic>\n \u2009=\u200940) or placebo (\n n<\/jats:italic>\n \u2009=\u200920). Half of the enrolled subjects were female. Subjects took one oral dose of their assigned treatment daily. Assessments were performed at baseline, Day 56 and Day 90. Preliminary 90\u2010day results are presented here.\n <\/jats:p>\n <\/jats:sec>\n \n Patients\/Methods<\/jats:title>\n \n The active group showed significant improvement in terminal hair count from baseline in anterior (\n p<\/jats:italic>\n \u2009<\u20090.0007) and posterior (\n p<\/jats:italic>\n \u2009<\u20090.0005) areas. Compared to placebo, the improvement was also significant in the anterior (\n p<\/jats:italic>\n \u2009<\u20090.05) and posterior (\n p<\/jats:italic>\n \u2009<\u20090.03) areas. Anterior vellus hair count improved significantly versus baseline (\n p<\/jats:italic>\n \u2009<\u20090.0005) and placebo (\n p<\/jats:italic>\n \u2009<\u20090.01). Posterior vellus hair count showed significant within\u2010group growth (\n p<\/jats:italic>\n \u2009<\u20090.05). Total hair count was significantly greater than baseline for anterior (\n p<\/jats:italic>\n \u2009<\u20090.001) and posterior (\n p<\/jats:italic>\n \u2009<\u20090.0005) and significantly greater for anterior (\n p<\/jats:italic>\n \u2009<\u20090.005) and posterior (\n p<\/jats:italic>\n \u2009<\u20090.05) compared to placebo. Total terminal hair counts improved 7\u2010fold, and total hair count improved 12\u2010fold compared to placebo. A significant reduction in hair shedding was observed in the active group versus baseline (\n p<\/jats:italic>\n \u2009<\u20090.05). No meaningful improvements were observed in the placebo group, and no adverse events were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These preliminary results indicate the daily administration of a proprietary saw palmetto (\n \n Serenoa repens<\/jats:italic>\n <\/jats:styled-content>\n ) extract safely and effectively promotes hair growth in men and women with self\u2010perceived thinning hair.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n Clinicaltrials.gov<\/jats:ext-link>\n identifier: NCT06920758\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70585","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:59:40Z","timestamp":1764511180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Safety and Efficacy of a Proprietary Bioactive Fatty Acids Extract From Saw Palmetto (\n \n Serenoa repens<\/i>\n <\/scp>\n ) for Promoting Hair Growth and Reducing Hair Loss in Adults With Self\u2010Perceived Thinning Hair: 90\u2010Day Results"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-2717","authenticated-orcid":false,"given":"Glynis","family":"Ablon","sequence":"first","affiliation":[{"name":"Ablon Skin Institute and Research Center Manhattan Beach California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S377009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2023.07.005"},{"key":"e_1_2_11_4_1","first-page":"397","article-title":"Epidemiology and Burden of Alopecia Areata: A Systematic Review","volume":"8","author":"Villasante Fricke A. C.","year":"2015","journal-title":"Clinical, Cosmetic and Investigational Dermatology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70167"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.07.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1721463"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10102.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2025.020"},{"key":"e_1_2_11_10_1","volume-title":"Litfulo (Ritlecitinib) Capsules [Prescribing Information]","author":"Pfizer","year":"2023"},{"key":"e_1_2_11_11_1","first-page":"1","article-title":"The Use of Serenoa repens (Saw Palmetto) in Hair Care Products","volume":"13","author":"Igielska Kalwat J.","year":"2019","journal-title":"Biomedical Journal of Scientific & Technical Research"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509905"},{"key":"e_1_2_11_13_1","first-page":"41","article-title":"Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract (SPSE) for 5\u03b1\u2010Reductase Isoform II Inhibition Using a Cell\u2010Free In\u00a0Vitro Test System","volume":"8","author":"Pais P.","year":"2016","journal-title":"Research and Reports in Urology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12352"},{"key":"e_1_2_11_15_1","first-page":"558","article-title":"A Six\u2010Month, Randomized, Double\u2010Blind, Placebo\u2010Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self\u2010Perceived Thinning Hair","volume":"17","author":"Ablon G.","year":"2018","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287211418725"},{"key":"e_1_2_11_17_1","first-page":"1","article-title":"Clinical Outcome of the Topical Application of a Novel Hair Growth Ingredient, USPlus DERM, in Men and Women","volume":"13","author":"Hill W. S.","year":"2025","journal-title":"Journal of Clinical and Investigative Dermatology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.58554"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17079"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/uro3010005"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076020"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00621.x"},{"key":"e_1_2_11_23_1","volume-title":"Propecia (Finasteride) Tablets [Prescribing Information]","author":"Merck Sharp & Dohme Corp","year":"2021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309849"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2018.3.199"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/107555302317371433"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201202500435"},{"key":"e_1_2_11_28_1","first-page":"27","article-title":"Oral Supplementation With l\u2010Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double\u2010Blind, Placebo\u2010Controlled, Randomized Clinical Study","volume":"11","author":"Piquero\u2010Casals J.","year":"2025","journal-title":"Skin Appendage Disorders"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:28:34Z","timestamp":1766428114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jocd.70585"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70585","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70585"}}