{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:21:33Z","timestamp":1769278893195,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Keratosis pilaris (KP) is a common follicular keratotic skin disorder characterized by follicular papules and skin roughness, often accompanied by itching and inflammation, significantly affecting appearance and psychological health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This 28\u2010day prospective, open\u2010label, randomized controlled study evaluated the effectiveness of a novel combined formula for KP treatment. The formula included a scrub (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Olea europaea<\/jats:italic>\n                      <\/jats:styled-content>\n                      shell powder, hydrated silica, and papain) and a moisturizing lotion with plant oils (peony seed oil, oat kernel oil, and rice bran oil). Sixty KP patients aged 18\u201335 were randomly assigned to a control group (salicylic acid body lotion) or a study group (combined formula), with 30 participants each. Evaluations included follicular papule counts, transepidermal water loss (TEWL), and depression scale scores at baseline (D0), day 7 (D7), day 14 (D14), day 21 (D21), and day 28 (D28). After D28, a self\u2010assessment questionnaire was used to compare treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to the repeated\u2010measures ANOVA, the control and study group had a significant reduction in follicular papule counts over time (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). For TEWL values, a significant simple effect of time was observed in the study group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), whereas the control group showed only a marginal change (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.054). Despite the absence of a significant main group effect (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.287), these results suggest that the study group achieved a greater overall improvement in skin barrier function over time. In the self\u2010assessment, 21 out of 23 indicators had higher effectiveness rates in the study group than the control group, with 96.7% effectiveness in improving skin dryness, smoothness, roughness, freshness, oiliness, and oil control. Depression scale scores were significantly affected by both time and group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008, respectively), indicating psychological improvement after 28\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined formula effectively reduced follicular papules, improved skin hydration, decreased TEWL, and alleviated depressive symptoms in KP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70605","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:37:31Z","timestamp":1766579851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Innovative Formula for Keratosis Pilaris Treatment\u2014A Randomized Controlled Study Based on the \u201cExfoliation\u2010Dissolution\u2010Repair\u201d Concept"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-2727","authenticated-orcid":false,"given":"Fangzhou","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co. Ltd.  Ji'nan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co. Ltd.  Ji'nan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5080-8530","authenticated-orcid":false,"given":"Tuowei","family":"Li","sequence":"additional","affiliation":[{"name":"South China University of Technology  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"EviSkin Testing Technology (Beijing) Co. Ltd.  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Zhang","sequence":"additional","affiliation":[{"name":"EviSkin Testing Technology (Beijing) Co. Ltd.  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengwei","family":"Qi","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co. Ltd.  Ji'nan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanbai","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical Sciences  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yexiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co. Ltd.  Ji'nan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-5864","authenticated-orcid":false,"given":"Hong","family":"Meng","sequence":"additional","affiliation":[{"name":"International School of Cosmetics Beijing Technology and Business University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.111215"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.12.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb03406.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2018.05.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1611"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1988.tb00688.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2784-8671.23.07594-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0368-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119829072"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529487"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.05933.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1818678"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae066"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/1033\/1\/012049"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/414\/1\/012004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.671914"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34830"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/205012"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO04094A"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0301-1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118354100"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010070"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.01.063"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-9-44"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:15:30Z","timestamp":1769228130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jocd.70605"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70605","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"2025-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70605"}}