{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:32:30Z","timestamp":1791149550368,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trifarotene, a fourth\u2010generation topical retinoid, offers a novel therapeutic option for facial and truncal acne. However, its role was only briefly addressed in Malaysia's 2022 Clinical Practice Guidelines (CPGs) due to its unavailability at the time. This paper aims to provide expert advisory statements on the integration of trifarotene into acne management in Malaysia, addressing evidence gaps in guideline coverage, particularly for truncal acne and acne\u2010induced sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature review was conducted to synthesize evidence on trifarotene's efficacy, safety, and clinical positioning. An advisory panel of 10 Malaysian dermatologists reviewed the evidence and provided consensus through structured surveys and discussion meetings. Three illustrative case studies were included to demonstrate the real\u2010world application of trifarotene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten advisory statements were finalized, addressing trifarotene's role in acne algorithms, patient selection, dosing strategies, combination therapy, and management of acne sequelae. Evidence supports its use for both facial and truncal acne, with additional benefits in acne\u2010induced hyperpigmentation and atrophic scarring. The panel recommended practical approaches to optimize tolerability and adherence, such as the CTMP (Cleanse\u2010Treat\u2010Moisturize\u2010Photoprotect) regimen and incremental application strategies. Real\u2010world cases demonstrated trifarotene's utility in diverse clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These advisory statements provide clinical guidance on the use of trifarotene in Malaysia and support its integration into routine acne management. As current CPGs may remain unchanged in the near term, these recommendations aim to inform evidence\u2010based practice while bridging gaps in local dermatologic care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70625","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:02:13Z","timestamp":1766988133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging Gaps in Malaysian Acne Vulgaris Guidelines: Advisory Statements on Trifarotene for Facial and Truncal Acne"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-0078","authenticated-orcid":false,"given":"Azura","family":"Mohd Affandi","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Kuala Lumpur  Kuala Lumpur Ministry of Health Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5273-0704","authenticated-orcid":false,"given":"Peter Wee Beng","family":"Ch'ng","sequence":"additional","affiliation":[{"name":"Peter Ch'ng Clinic  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benji Tze Yuen","family":"Teoh","sequence":"additional","affiliation":[{"name":"Central Dermatology  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-4673","authenticated-orcid":false,"given":"Evelyn Wen Yee","family":"Yap","sequence":"additional","affiliation":[{"name":"Mahkota Medical Centre  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-9959","authenticated-orcid":false,"given":"Chin Chwen","family":"Ch'ng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Subang Jaya Medical Centre  Subang Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-8597","authenticated-orcid":false,"given":"Seow Hoong","family":"Foo","sequence":"additional","affiliation":[{"name":"Gleneagles Hospital Johor  Iskandar Puteri Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-9804","authenticated-orcid":false,"given":"Kang Nien","family":"How","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Faculty of Medicine and Health Sciences Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-0087","authenticated-orcid":false,"given":"Zhenli","family":"Kwan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-8274","authenticated-orcid":false,"given":"Jyh Jong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Raja Permaisuri Bainun  Ipoh Ministry of Health Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-0974","authenticated-orcid":false,"given":"Wooi Chiang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Pulau Pinang  George Town Ministry of Health Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khen","family":"Kon","sequence":"additional","affiliation":[{"name":"Galderma  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Thian","family":"Poh","sequence":"additional","affiliation":[{"name":"Galderma  Petaling Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.017"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae352"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010024\u201001175\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010020\u201000417\u20104"},{"issue":"3","key":"e_1_2_13_7_1","first-page":"263","article-title":"The Effect of Medical Education and Counselling on Treatment Adherence and Disease Severity in Patients With Acne Vulgaris: A Non\u2010Randomised Interventional Study","volume":"78","author":"Ling W. 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