{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:49:49Z","timestamp":1790912989298,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet\u2010rich plasma (PRP) shows promise in burn management, yet optimal platelet concentrations, timing, and standardized protocols remain unclear, leading to inconsistent clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the therapeutic efficacy of PRP at different platelet concentrations in deep second\u2010degree burns and to explore associated molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight patients with small\u2010area deep second\u2010degree burns were randomly assigned to four groups: Group A (PRP 600\u20131000\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L), Group B (normal saline control), Group C (PRP 1000\u20131400\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L), and Group D (PRP 1400\u20131800\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L). Outcomes included wound healing time, wound coverage rates at 2 and 3\u2009weeks, bacterial culture positivity, and 3\u2010month scar scores. Full\u2010thickness biopsies were collected on days 5, 9, and 16 for histopathology, immunohistochemistry, and growth factor quantification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All PRP groups showed faster healing and lower infection rates compared with controls. Group C achieved the shortest healing time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Growth factor concentrations rose with increasing platelet levels, but M2 macrophage polarization was highest in Group C. Elevated transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) in Group D appeared to trigger negative feedback, limiting M2 accumulation and diminishing added benefit. Scar scores did not differ significantly among PRP groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      PRP accelerates wound healing and reduces infection risk in deep second\u2010degree burns. A platelet concentration of 1000\u20131400\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L provides the best therapeutic balance. Excessively high concentrations may impair repair through TGF\u2010\u03b2\u2013mediated inhibitory effects. Future research should explore controlled\u2010release strategies to optimize PRP\u2010derived growth factor activity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70633","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:05:59Z","timestamp":1766988359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential Therapeutic Efficacy of Autologous Platelet\u2010Rich Plasma at Varying Concentrations in the Treatment of Deep Second\u2010Degree Burn and Its Underlying Molecular Mechanisms"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-2138","authenticated-orcid":false,"given":"Yu\u2010Fei","family":"Zhao","sequence":"first","affiliation":[{"name":"The Ninth People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-0521","authenticated-orcid":false,"given":"Yi","family":"Pan","sequence":"additional","affiliation":[{"name":"The Ninth People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7264-8072","authenticated-orcid":false,"given":"Hong\u2010Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"The Ninth People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-0154","authenticated-orcid":false,"given":"Fu\u2010Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Ninth People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5730-3869","authenticated-orcid":false,"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"The Ninth People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1807442"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193073"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216357"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19031338"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.11.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2020.11.005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524353"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_269_21"},{"issue":"5","key":"e_1_2_11_11_1","first-page":"281","article-title":"Platelet\u2010Rich Plasma in Regenerative Medicine: Possible Applications in Management of Burns and Post\u2010Burn Scars: A Review","volume":"25","author":"Hosseini M. 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