{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:11:04Z","timestamp":1790989864159,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172091"],"award-info":[{"award-number":["82172091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402450"],"award-info":[{"award-number":["82402450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372122"],"award-info":[{"award-number":["82372122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20245"],"award-info":[{"award-number":["U25A20245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Collagen is essential for maintaining skin structure and function, and the circadian rhythm is known to regulate a wide range of physiological processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate whether collagen metabolism in human skin fibroblasts exhibits circadian regulation, and to evaluate whether the time\u2010coordinated application of baicalin at daytime and palmitoyl tripeptide\u20101 (PT\u20101) at nighttime synergistically promotes collagen fiber formation and improves overall skin quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A circadian\u2010synchronized human skin fibroblast model was established. The expression of collagen metabolism\u2010related genes was analyzed using qPCR and immunofluorescence. Subsequently, an 8\u2010week topical application study was conducted in mice using a regimen of daytime baicalin and nighttime PT\u20101. Finally, a clinical trial involving 30 female participants was conducted, employing the same time\u2010coordinated application scheme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fibroblasts exhibited opposing day\u2010night rhythms: genes for collagen assembly (e.g., LOX) peaked during the day, while those involved in synthesis\/secretion (e.g., Sec61a2, Mia3, Pde4d, Vps33b) and degradation (e.g., CTSK, MMP1) peaked at night. Time phase\u2010dependent interventions showed baicalin enhanced daytime assembly, while PT\u20101 boosted nighttime synthesis. In mice, a timed day\u2010night combination therapy increased collagen fiber density. Clinical trial (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) confirmed the efficacy, showing significant improvements in skin luminance (+16.29%), nasolabial fold depth (\u221236.35%), and firmness (R2: +24.35%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collagen metabolism is regulated by circadian rhythms. Chronomodulated baicalin and PT\u20101 application synergistically optimize collagen metabolism and improve skin quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70638","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:37:34Z","timestamp":1768293454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8641-4696","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai East Hospital, School of Medicine Tongji University  Shanghai P. R. 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