{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:39:58Z","timestamp":1773009598457,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and Objectives<\/jats:title>\n                    <jats:p>\n                      Dermocosmetics have proven their benefit in acne management. However, only very few studies investigated their efficacy kinetics. This study assessed the efficacy kinetics of a dermocosmetic cream (DC) containing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Punica granatum<\/jats:italic>\n                      <\/jats:styled-content>\n                      Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and\n                      <jats:italic>Aqua Posae Filiformis<\/jats:italic>\n                      in subjects with acne.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>16 subjects (14 women, 2 men; mean age 29.4\u2009\u00b1\u20097.7\u2009years; phototype II and III) with mild to moderate acne participated in a randomized, intra\u2010individual, split\u2010face\u00a0study for 15\u2009days. Hemi\u2010faces randomly received DC or remained untreated. Assessments included lesion counts, acne severity, and local tolerance; subjects also rated the perceived benefit of the DC. Efficacy was also evaluated using standardized multi\u2010modality full\u2010face imaging and a mobile connected imaging system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The inflammatory lesion count significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05) decreased with DC at Day 8 and Day 15; a significant decrease of the non\u2010inflammatory lesion count was observed at Day 15 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The total lesion count had significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05) decreased with DC at Day 8 and Day 15. Between\u2010side differences were significant (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05) for all lesion types at D15. Local tolerance was good. Most subjects considered that their skin appearance and the visibility of acne lesions had improved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This exploratory study provides strong evidence on the efficacy kinetics of a DC cream in acne management in subjects with fair skin tones. It shows that early, daily and specific treatment with a targeted DC significantly improves all acne lesions type, as well as acne severity as soon as 15\u2009days.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70641","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T09:27:23Z","timestamp":1767605243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split\u2010Face Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Catherine","family":"Queille\u2010Roussel","sequence":"first","affiliation":[{"name":"CPCAD, CHU l'Archet  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9950-3734","authenticated-orcid":false,"given":"James","family":"Odeimi","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Broallier","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4261","authenticated-orcid":false,"given":"Delphine","family":"Kerob","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Windsor Clinical Research Inc Western University  Windsor Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04214.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.035"},{"issue":"6","key":"e_1_2_11_4_1","first-page":"566","article-title":"Prospective Study of Pathogenesis of Atrophic Acne Scars and Role of Macular Erythema","volume":"16","author":"Tan J.","year":"2017","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12706"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1425675"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.045377"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13776"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20145"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"65","article-title":"Comedolysis by a Lipohydroxyacid Formulation in Acne\u2010Prone Subjects","volume":"13","author":"Uhoda E.","year":"2003","journal-title":"European Journal of Dermatology"},{"issue":"5","key":"e_1_2_11_12_1","first-page":"1","article-title":"Vitamin B Derivative (Nicotinamide)appears to Reduce Skin Cancer Risk","volume":"22","author":"Nazarali S.","year":"2017","journal-title":"Skin Therapy Letter"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2130-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00296.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16052"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.017"},{"key":"e_1_2_11_18_1","volume-title":"StatPearls","author":"Sutaria A. 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