{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T23:00:11Z","timestamp":1769295611011,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Submental fullness (\u201cdouble chin\u201d) is a common aesthetic concern among Indian women. No topical cosmeceutical has been systematically evaluated for this indication.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess the efficacy of a multi\u2010active topical serum containing DMAE and retinol in reducing submental fullness in Indian women.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This 12\u2010week, single\u2010center, open\u2010label study enrolled 16 women (ages 18\u201360) with mild\u2010to\u2010moderate submental fullness; 13 completed the trial. Subjects applied the serum nightly to the submental area. Standardized photographs were obtained at baseline and week 12 and were independently graded by two dermatologists using the validated Clinician\u2010Reported Submental Fat Rating Scale. Any discordance was evaluated and resolved by a third, umpire dermatologist. Body weight was monitored throughout.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All 13 completers showed visible improvement in submental contour. Dermatologist grading showed statistically significant improvements across all three views (\n p<\/jats:italic>\n \u2009<\u20090.05), with the maximum change noted in the left and front profiles (\n r<\/jats:italic>\n \u2009=\u20090.88 and 0.83, respectively) compared to the right profile (\n r<\/jats:italic>\n \u2009=\u20090.61). Improvements were independent of body weight changes. No adverse events occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This preliminary study demonstrates that a DMAE and retinol based topical serum can improve submental fullness in Indian women over 12\u2009weeks, offering a noninvasive alternative to procedural interventions. Larger randomized controlled trials with objective volumetric endpoints are needed for validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70653","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T08:45:45Z","timestamp":1767602745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Topical Cosmeceutical Approach to Submental Fullness in Indian Women: 12\u2010Week Prospective Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Subashini","family":"Selavdurairaj","sequence":"first","affiliation":[{"name":"Silphion Research Private Limited Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0666-6739","authenticated-orcid":false,"given":"Savitha","family":"Murali","sequence":"additional","affiliation":[{"name":"Silphion Research Private Limited Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivavallinathan","family":"Arunachalam","sequence":"additional","affiliation":[{"name":"Render Skin & Hair Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragavi","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Silphion Research Private Limited Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-8566","authenticated-orcid":false,"given":"C.","family":"Divyalakshmi","sequence":"additional","affiliation":[{"name":"Silphion Research Private Limited Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanathi","family":"Thirunavukkarasu","sequence":"additional","affiliation":[{"name":"Silphion Research Private Limited Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Anannya","sequence":"additional","affiliation":[{"name":"Render Skin & Hair Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavithra","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Silphion Research Private Limited Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001648"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002580"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12762"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15497"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100625.2002.110502.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab347"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjprs.2024.12.003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071\u2010200506010\u201000005"},{"issue":"12","key":"e_1_2_12_10_1","first-page":"818","article-title":"In Vivo Skin Effects of a Dimethylaminoethanol (DMAE) Based Formulation","volume":"64","author":"Tadini K. A.","year":"2009","journal-title":"Die Pharmazie"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100846.2002.10295.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010022\u201002319\u20107"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030290"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001155"},{"key":"e_1_2_12_15_1","volume-title":"ISAPS International Survey on Aesthetic\/Cosmetic Procedures Performed in 2024","author":"International Society of Aesthetic Plastic Surgery","year":"2025"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:14:33Z","timestamp":1769228073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jocd.70653"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70653","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70653"}}