{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:37:46Z","timestamp":1786117066592,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intradermal botulinum toxin injections have been shown to reduce sebaceous gland activity and improve skin texture in patients with oily and acne\u2010prone skin. However, needle\u2010based application is associated with discomfort and potential side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy and safety of transdermal delivery of botulinum toxin (150 kDa) using Transdermal Application (TDA) technology for the treatment of oily and acne\u2010prone skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center observational study, 19 participants (aged 20\u201350) underwent treatment with the DERMADROP MED TDA device according to the BIOBOTOX protocol. Objective assessments included Sebumeter measurements and 2D\/3D skin imaging. Subjective evaluation was conducted using validated patient\u2010reported outcome measures (OSIS, OSSAS) at baseline, 2\u2009weeks, and 4\u2009weeks posttreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A statistically significant reduction in sebum levels was observed, accompanied by notable improvements in self\u2010reported skin clarity and satisfaction. No adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transdermal application of botulinum toxin using TDA\u2010based DERMADROP MED technology is a safe, well\u2010tolerated, and effective noninvasive treatment modality for reducing sebaceous activity and improving the appearance of oily and acne\u2010prone skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70656","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:22:10Z","timestamp":1770445330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transdermal Delivery of Botulinum Toxin for the Management of Oily and Acne\u2010Prone Skin Using\n                    <scp>TDA<\/scp>\n                    Technology"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8749-9919","authenticated-orcid":false,"given":"Stephanie","family":"Schulz","sequence":"first","affiliation":[{"name":"Meddrop BioMedical Technologies GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-5237","authenticated-orcid":false,"given":"Sophie","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Arc Clinic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12097"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13110817"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad044"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006084"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2006.10.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S202919"},{"key":"e_1_2_13_8_1","doi-asserted-by":"crossref","unstructured":"A.Cammarano S.Dello Iacono C.Meglio andL.Nicolais \u201cAdvances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis \u201dhttps:\/\/doi.org\/10.20944\/preprints202312.0340.v1.","DOI":"10.20944\/preprints202312.0340.v1"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115748863362068250122102544"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100625.2000.009003165.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201052772915"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122722"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010024\u201004064\u20101"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001307010057"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.08.443"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010020\u201000393\u20109"},{"key":"e_1_2_13_17_1","unstructured":"F.vonHahn DERMADROP TDA: Technology Insights Mode of Action Clinical Work. Internal technical white paper (Meddrop BioMedical Technologies GmbH 2023)."},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169\u2010409X(02)00118\u20107"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1504"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.07.016"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1461\u20105347(00)00295\u20109"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2006.10.019"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000045235.86197.ef"},{"key":"e_1_2_13_24_1","unstructured":"R.ArbuckelandN.Bonner \u201cScoring Manual for the Oily Skin Self Assessment Scale (OSSAS) und Oily Skin Impact Scale (OSIS) \u201d(2008) Technical report PI5542B Version 3.0. Prepared for Pfizer Inc. Mapi Values Ltd."},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104733.2009.00504.x"},{"key":"e_1_2_13_26_1","unstructured":"Courage + Khazaka Electronic GmbH \u201cSebumeter SM 815: Information und Instruction Manual. Cologne Germany \u201d(2024) Manufacturer technical documentation."},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071\u2010200506030\u201000001"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.190102"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:08:48Z","timestamp":1786021728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jocd.70656"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70656","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70656"}}