{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T23:12:28Z","timestamp":1769296348437,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Superior sulcus hollowing is a frequent esthetic concern, commonly managed with synthetic fillers or fat grafts; however, these approaches carry potential risks and costs. Injectable platelet\u2010rich fibrin (i\u2010PRF), an autologous regenerative biomaterial, has shown promise in dermatologic and dental applications, but its use for periocular volume restoration remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy, safety, and patient satisfaction of i\u2010PRF injections for the correction of superior sulcus hollowing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective study included 24 eyes of 12 patients treated with i\u2010PRF between 2021 and 2024. Sulcus depth was measured at baseline and at 3 and 6\u2009months posttreatment. Subjective satisfaction was assessed using a binary scale. i\u2010PRF was prepared using a low\u2010speed centrifugation protocol and injected suborbicularis in three sessions spaced 1\u2009week apart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant reduction in superior sulcus depth was observed from baseline to 3\u2009months (13.3\u2009\u00b1\u20092.8\u2009mm to 9.2\u2009\u00b1\u20093.7\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), followed by mild regression at 6\u2009months (10.5\u2009\u00b1\u20093.3\u2009mm). Patient satisfaction was high, with 18 out of 24 eyes (75%) reporting favorable outcomes at 3\u2009months. No adverse effects were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This first clinical report of i\u2010PRF for upper eyelid hollowing suggests that it may serve as a safe, autologous, and minimally invasive alternative for superior sulcus volume restoration. Further prospective studies with standardized outcome measures are warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70666","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:55:47Z","timestamp":1768978547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Application of Injectable\n                    <scp>PRF<\/scp>\n                    for Superior Sulcus Hollowing"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-9786","authenticated-orcid":false,"given":"Nese","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Saglik Bilimleri Universitesi Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-5551","authenticated-orcid":false,"given":"Alperen","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Saglik Bilimleri Universitesi Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Alp","family":"Bilgic","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology SBU Ulucanlar Goz Egitim Ve Arastirma Hastanesi  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5750-6825","authenticated-orcid":false,"given":"\u015eule Barman","family":"Kakil","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology FEBO, Mustafa Kemal Universitesi Tayfur Ata Sokmen Tip Fakultesi  Antakya Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-003-0066-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00266-010-9574-y","article-title":"Correction of Superior Sulcus Deformity With Orbital Fat Anatomic Repositioning and Fat Graft Applied to Retro\u2010Orbicularis Oculi Fat for Asian Eyelids","volume":"35","author":"Park S.","year":"2011","journal-title":"Aesthetic Plastic Surgery"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000141"},{"key":"e_1_2_12_5_1","first-page":"55","article-title":"PRF: An Opportunity in Perio\u2010Implantology","volume":"42","author":"Choukroun 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