{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:45:27Z","timestamp":1792251927409,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574002"],"award-info":[{"award-number":["82574002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Intense pulsed light (\n IPL<\/jats:styled-content>\n ) therapy is widely used for facial rejuvenation, targeting vascular, pigmentary, and textural changes. However, comprehensive, real\u2010world evidence evaluating long\u2010term, regular\n IPL<\/jats:styled-content>\n treatment across multiple dimensions of skin improvement remains limited.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study aimed to assess the efficacy and safety of long\u2010term, regular\n IPL<\/jats:styled-content>\n therapy in improving facial erythema, pigmentation, and wrinkles, and to identify predictors of favorable response.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective real\u2010world study included 236 patients who underwent six or more\n IPL<\/jats:styled-content>\n sessions between 2020 and 2025. Patients were categorized as acne, rosacea, or cosmetic subjects.\n VISIA<\/jats:styled-content>\n imaging quantified erythema, pigmentation, and wrinkle indices, while the Global Aesthetic Improvement Scale (\n GAIS<\/jats:styled-content>\n ) was used to assess aesthetic outcomes. Logistic regression identified predictors of good response.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant improvements were observed in erythema, pigmentation, and wrinkle indices after treatment (all\n p<\/jats:italic>\n \u2009<\u20090.05). Regular treatment intervals and total number of sessions were independently associated with better outcomes (\n OR<\/jats:styled-content>\n \u2009=\u200913.62 and 3.80, respectively, both\n p<\/jats:italic>\n \u2009<\u20090.05). Patients with Fitzpatrick Type\n IV<\/jats:styled-content>\n skin showed lower response rates (\n OR<\/jats:styled-content>\n \u2009=\u20090.12,\n p<\/jats:italic>\n \u2009=\u20090.001).\n VISIA<\/jats:styled-content>\n analyses demonstrated quantifiable reductions in erythema and pigmentation areas, while wrinkles showed notable textural improvement. No severe adverse events occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Long\u2010term, regular\n IPL<\/jats:styled-content>\n therapy effectively improves facial erythema, pigmentation, and wrinkles, confirming its value as a comprehensive rejuvenation strategy. Regular treatment intervals optimize cumulative effects, while objective imaging enhances precision in outcome evaluation. These findings support\n IPL<\/jats:styled-content>\n as a safe, evidence\u2010based, and multidimensional approach to long\u2010term facial rejuvenation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70691","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:22:45Z","timestamp":1769412165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive Facial Skin Rejuvenation With Long\u2010Term Regular Intense Pulsed Light Therapy: A Real\u2010World Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-5767","authenticated-orcid":false,"given":"Birao","family":"Fan","sequence":"first","affiliation":[{"name":"Department Of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-4847","authenticated-orcid":false,"given":"Ruixing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department Of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics12050199"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14113867"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010021\u201000607\u20108"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_1029_2022"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S389705"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13338"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70357"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13194"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S380388"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2010.514920"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14802"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010020\u201001637\u2010x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010022\u201001635\u20106"},{"issue":"20","key":"e_1_2_13_15_1","first-page":"1394","article-title":"Identification of Pathogenic Mutations in Two Chinese Families Affected With Primary Localized Cutaneous Amyloidosis","volume":"87","author":"Feng Y. J.","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac175"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010023\u201003590\u2010x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S450081"},{"key":"e_1_2_13_19_1","volume-title":"StatPearls","author":"Sharma A. N.","year":"2023"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:09:00Z","timestamp":1786021740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jocd.70691"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70691","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,25]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70691"}}