{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:38:34Z","timestamp":1786117114712,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intense pulsed light (IPL) therapy is widely used for skin rejuvenation but frequently induces transient skin barrier impairment, erythema, and discomfort. Post\u2010procedure skincare targeting barrier repair and symptom relief remains a clinical priority.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy, safety, and satisfaction of a cream containing 4\u2010tert\u2010butylcyclohexanol,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Tephrosia purpurea<\/jats:italic>\n                      <\/jats:styled-content>\n                      seed extract, and\n                      <jats:italic>Schisandra sphenanthera<\/jats:italic>\n                      extract (TTS cream) in facilitating skin recovery after IPL therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, double\u2010blind, split\u2010face study, 30 healthy female subjects received IPL therapy. One hemiface was randomly applied TTS cream, and the contralateral side was applied a control moisturizing toner after IPL. Objective instrument assessments were conducted at baseline (D0), post\u2010IPL (D0\u2032), 30\u2009min post\u2010application (D30min), and on days 3 (D3), 7 (D7), 14 (D14), and 28 (D28). Subjective assessments and satisfaction surveys were concurrently collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IPL therapy significantly increased TEWL, erythema, and skin dehydration at D0\u2032 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). At D30min, compared to the control, TTS cream significantly improved skin hydration (\u2206\u2009=\u200912.79 vs. 0.32 C.U.,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). At D28, TTS cream significantly reduced erythema index (\u2206\u2009=\u2009\u221254.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), erythema area (\u2206\u2009=\u2009\u22127.02%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and TEWL (\u2206\u2009=\u2009\u22124.41\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      \u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Subjective assessments confirmed TTS cream significantly alleviated stinging, burning, and redness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Satisfaction rates reached 100% for gentleness and 96.67% for symptom relief. No adverse effects were reported throughout the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that the TTS cream effectively enhances skin barrier recovery, reduces erythema, and relieves discomfort following IPL therapy, highlighting its potential application in the postoperative care of aesthetic medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70697","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:40:19Z","timestamp":1770010819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Evaluation of a Cream With Advanced Soothing Complex for Skin Recovery Following Intense Pulsed Light Therapy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4610-0554","authenticated-orcid":false,"given":"Jianhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangdong Sensitive Skin Care Engineering Technology Research Center  Guangzhou Guangdong China"},{"name":"Simcare Biotechnology Group Co., Ltd.  Guangzhou Guangdong China"},{"name":"N.O.D. Topia (Hongkong) Biotechnology Co., Ltd.  Hongkong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichao","family":"Liu","sequence":"additional","affiliation":[{"name":"Simcare Biotechnology Group Co., Ltd.  Guangzhou Guangdong China"},{"name":"N.O.D. Topia (Hongkong) Biotechnology Co., Ltd.  Hongkong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong Sensitive Skin Care Engineering Technology Research Center  Guangzhou Guangdong China"},{"name":"Simcare Biotechnology Group Co., Ltd.  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Sensitive Skin Care Engineering Technology Research Center  Guangzhou Guangdong China"},{"name":"Simcare Biotechnology Group Co., Ltd.  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-9048","authenticated-orcid":false,"given":"Li","family":"Ye","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou Guangdong China"},{"name":"Hygiene Detection Center, School of Public Health Southern Medical University (NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research)  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03620-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4139"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-021-02283-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70357"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16285"},{"key":"e_1_2_12_7_1","article-title":"Laser and Photoepilation for Unwanted Hair Growth","volume":"4","author":"Haedersdal M.","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-018-0141-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01635-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16281"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12461"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19857"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70350"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.13075"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13529"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6657"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13047"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-018-9582-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23879"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807222115"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6165"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_1029_2022"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2019.4626"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23650"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1024598"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093939"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.03.129"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051424"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12765"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.59918"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061341"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13530"},{"issue":"4","key":"e_1_2_12_33_1","first-page":"199","article-title":"Pain\u2010Resolving Immune Mechanisms in Neuropathic Pain","volume":"19","author":"Fiore N. 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