{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:37:45Z","timestamp":1786117065678,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2023MS108"],"award-info":[{"award-number":["2023MS108"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acne is a common skin condition that seriously affects the physical and mental health of patients. In addition to the standard acne treatment, anti\u2010acne skin care products are gradually becoming essential in preventing and treating acne. Herbal Balance Solution contains multiple botanical ingredients with potential anti\u2010inflammatory and barrier\u2010supportive properties. This pilot study aimed to explore the safety and preliminary clinical effects of Herbal Balance Solution in patients with mild\u2010to\u2010moderate acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three patients with mild or moderate acne vulgaris were treated with Herbal Balance Solution once every 3\u2009days for 4\u2009weeks. At baseline (Week 0, W0), Week 2 (W2), and Week 4 (W4), acne lesion counts (total, inflammatory, and non\u2010inflammatory lesions) and the severity index were measured to assess the treatment efficacy, and transepidermal water loss was tested to assess face irritation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The number of closed comedones was significantly reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) at each time point after using the test product. Furthermore, the transepidermal water loss rate significantly decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). At Week 4, reductions in total inflammatory and non\u2010inflammatory lesion counts were observed and were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this open\u2010label pilot study, use of Herbal Balance Solution was associated with short\u2010term improvements in acne\u2010related clinical parameters and skin barrier function and was well tolerated in patients with mild\u2010to\u2010moderate acne vulgaris. These preliminary findings warrant confirmation in randomized, vehicle\u2010controlled clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70702","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:22:12Z","timestamp":1770445332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Preliminary Clinical Effects of a Herbal Balance Solution in Mild\u2010To\u2010Moderate Acne Vulgaris: An Open\u2010Label, Single\u2010Arm Pilot Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-6596","authenticated-orcid":false,"given":"Xiaoyue","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Dermatology West China Hospital, Sichuan University  Chengdu 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