{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:37:51Z","timestamp":1786117071394,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC\u2010YBMS\u2010633"],"award-info":[{"award-number":["2024JC\u2010YBMS\u2010633"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To construct a facial\u2010skincare adverse event atlas and detect category\u2010level safety signals using the US FDA openFDA Cosmetic Adverse Events database.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We analyzed publicly available openFDA cosmetic adverse event reports (downloaded 2025\u201012\u201015; meta.last_updated 2025\u201012\u201010). Suspect products were classified into 12 facial\u2010skincare subcategories using keyword rules, excluding hair, makeup, nail, fragrance, oral, deodorant, and bath\/body cleansing products. MedDRA preferred terms were grouped into nine clinically interpretable reaction clusters. Reporting odds ratios (RORs) with 95% confidence intervals were computed versus the full database (primary) and within\u2010cohort comparators (sensitivity), with false discovery rate (FDR) control. We performed \u201ccase\u2010check\u201d analyses for five prioritized signals to assess product concentration and temporal patterns.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The broad facial cohort comprised 2927 reports and the strict facial sensitivity cohort 1573 reports. The strongest full\u2010database signals were eye\u2010area products with ocular symptoms (ROR 61.67; 95% CI 46.13\u201382.43), masks with burn\u2010related events (ROR 27.95; 20.39\u201338.31), retinoid\/anti\u2010aging with swelling\/angioedema (ROR 21.94; 17.20\u201328.00), serum\/essence with ocular symptoms (ROR 17.82; 13.74\u201323.10), and exfoliant\/peel\/scrub with burn\u2010related events (ROR 13.39; 9.68\u201318.53). Within\u2010cohort comparators attenuated effect sizes but preserved core signals (e.g., eye\u2010area \u00d7 ocular symptoms within\u2010broad ROR 9.14; 6.68\u201312.49). Case\u2010check analyses showed low product\u2010name concentration across signals, supporting category\u2010level interpretation.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n openFDA cosmetovigilance data can be leveraged to map facial\u2010skincare adverse event patterns and prioritize plausible safety signals. Eye\u2010area products showed especially strong ocular\u2010related signals, and leave\u2010on products (masks, retinoid\/anti\u2010aging, serum\/essence) showed coherent burn\u2010 and swelling\u2010related signals.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70712","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:54:04Z","timestamp":1769838844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Facial Skincare Adverse Event Atlas and Safety Signals From\n openFDA<\/scp>\n Cosmetic Reports: A Disproportionality Analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2787-647X","authenticated-orcid":false,"given":"Zhe","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010200831050\u201000010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_447_18"},{"key":"e_1_2_10_4_1","unstructured":"US Food and Drug Administration \u201copenFDA: Cosmetic Adverse Events \u201d accessed December 15 2025 https:\/\/open.fda.gov\/apis\/cosmetic\/event\/."},{"key":"e_1_2_10_5_1","unstructured":"US Food and Drug Administration \u201copenFDA Data Downloads: Cosmetic Adverse Events (\/Cosmetic\/Event) \u201d accessed December 15 2025 https:\/\/open.fda.gov\/data\/downloads\/."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.2762"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14065"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pky026"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdsfr.2023.1323057"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010024\u201001421\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010024\u201001423\u20107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2023.04.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610\u20100387.2012.07939.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70712","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:09:28Z","timestamp":1786021768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jocd.70712"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70712","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70712"}}