{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:49:42Z","timestamp":1793573382119,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Hair loss remains a global concern for both men and women.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n This study assessed the efficacy and safety of a proprietary extract of bioactive fatty acids from saw palmetto (\n \n Serenoa repens<\/jats:italic>\n <\/jats:styled-content>\n ) for treating self\u2010perceived thinning hair in healthy adult men and women (SEREVELLE, Valensa International; Eustis, FL).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This 6\u2010month, randomized, double\u2010blind, placebo\u2010controlled study assessed the beneficial effects of daily active treatment (\n n<\/jats:italic>\n \u2009=\u200940) vs. placebo (\n n<\/jats:italic>\n \u2009=\u200920) on several hair growth parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Active treatment of SEREVELLE significantly outperformed placebo on all primary endpoints at Day 180. Mean (SD) change in baseline total terminal hair count was +18.6 (29.6) with active vs. \u201310.1 (30.5) with placebo (\n p<\/jats:italic>\n \u2009<\u20090.001; 283% greater improvement). Total vellus hair count increased +6.6 (15.6) vs. \u20132.1 (15.7) (\n p<\/jats:italic>\n \u2009<\u20090.05; 414% greater improvement). Total hair density rose +25.1 (27.7) vs. \u201312.2 (38.8) (\n p<\/jats:italic>\n \u2009<\u20090.001; 306% greater improvement). Subgroup analyses at Day 180 corroborated these advantages: across populations, between\u2010group differences in mean change favored active for subgroup of men, with total terminal hair count (\n p<\/jats:italic>\n \u2009=\u20090.003), total vellus hair count (\n p<\/jats:italic>\n \u2009<\u20090.001), and total hair density (\n p<\/jats:italic>\n \u2009<\u20090.001). In menopausal women, active produced significant placebo\u2010adjusted gains in total terminal hair count (\n p<\/jats:italic>\n \u2009<\u20090.05) and total hair density (\n p<\/jats:italic>\n \u2009<\u20090.01), with a nonsignificant numerical advantage for total vellus hair count. There were no treatment\u2010related adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The daily use of a proprietary saw palmetto (\n \n Serenoa repens<\/jats:italic>\n <\/jats:styled-content>\n ) extract safely and effectively promotes hair growth in men and women with self\u2010perceived thinning hair.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70717","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:11:26Z","timestamp":1770444686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Safety and Efficacy of a Novel Saw Palmetto (\n \n Serenoa repens<\/i>\n <\/scp>\n ) Extract for Promoting Hair Growth in Adults With Self\u2010Perceived Thinning Hair: 180\u2010Day Results"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-2717","authenticated-orcid":false,"given":"Glynis","family":"Ablon","sequence":"first","affiliation":[{"name":"Medical, Surgical, and Cosmetic Dermatology Ablon Skin Institute and Research Center Manhattan Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S377009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2025.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JW9.0000000000000227"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"The Use of Serenoa Repens (Saw Palmetto) in Hair Care Products","volume":"13","author":"Igielska Kalwat J.","year":"2019","journal-title":"Biomedical Journal of Scientific & Technical Research"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509905"},{"key":"e_1_2_8_7_1","first-page":"41","article-title":"Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract (SPSE) for 5\u03b1\u2010Reductase Isoform II Inhibition Using a Cell\u2010Free in Vitro Test System","volume":"8","author":"Pais P.","year":"2016","journal-title":"Research and Reports in Urology"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Clinical Outcome of the Topical Application of a Novel Hair Growth Ingredient, USPlus DERM, in Men and Women","volume":"13","author":"Hill W. S.","year":"2025","journal-title":"Journal of Clinical and Investigative Dermatology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70585"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.58554"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17079"},{"key":"e_1_2_8_12_1","first-page":"27","article-title":"Lipid Profile and 5\u03b1\u2010Reductase Inhibition Activity of Proprietary Ultrahigh\u2010Pressure Supercritical Carbon Dioxide and Hexane Saw Palmetto Extracts","volume":"3","author":"Cartwright E. J.","year":"2023","journal-title":"International Journal of Urology"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.70035"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S435795"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70717","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:09:38Z","timestamp":1786021778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jocd.70717"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70717","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70717"}}