{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:38:39Z","timestamp":1786117119270,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073472"],"award-info":[{"award-number":["82073472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong Municipality","doi-asserted-by":"publisher","award":["MS22022102"],"award-info":[{"award-number":["MS22022102"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Refractory rosacea can be effectively treated with fractional microneedle radiofrequency (FMR), but its optimal parameters need confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the optimal parameters of FMR in treating rosacea\u2010like dermatitis and the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A rosacea\u2010like dermatitis mouse model was intervened with FMR of varying pulse energy and width. By assessing the severity of erythema and measuring erythema area, optimal parameters of FMR to treat rosacea\u2010like dermatitis in mice were determined. Pathological staining was performed to examine the infiltration of inflammatory cells and CD31\n                      <jats:sup>+<\/jats:sup>\n                      microvessels. Expression levels of pro\u2010inflammatory factors were detected by qRT\u2010PCR. The involvement of the NF\u2010\u03baB signaling pathway and its downstream mediators (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1) in mice treated with low\u2010power short\u2010pulse\u2010width fractional microneedle radiofrequency (LS\u2010FMR) was detected using Western blotting. In a cohort of 20 patients with erythematotelangiectatic rosacea (ETR) and managed by one session of FMR treatment, therapeutic efficacy was assessed by Multispectral skin analysis system at 3\u2009months of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LS\u2010FMR at energy levels of 1, 2, 3 and 4\u2009W and pulse width of 20\u2009ms alleviated the severity of erythema and narrowed the erythema area in LL37\u2010induced mice. It significantly inhibited the infiltration of mast cells and CD4+ T cells, polarization of CD4+ T cells to Th1\/Th17 cells, angiogenesis, the activation of the NF\u2010\u03baB signaling pathway, as well as the expression of downstream inflammatory cytokines (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1). In a cohort of 20 ETR patients, just one session of FMR treatment significantly alleviated erythema at 3\u2009months of follow\u2010up, without obvious adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LS\u2010FMR is a promising approach to treat rosacea by suppressing skin immune responses and angiogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinical trial number: Not applicable<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70727","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:50:57Z","timestamp":1770702657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Power Short\u2010Pulse\u2010Width Fractional Microneedle Radiofrequency Relieves\n                    <scp>LL37<\/scp>\n                    \u2010Induced Rosacea\u2010Like Skin Inflammation"],"prefix":"10.1111","volume":"25","author":[{"given":"Zhiyi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"},{"name":"Medical School of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"},{"name":"Medical School of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"},{"name":"Medical School of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"},{"name":"Medical School of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong Institute of Liver Diseases Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-0519","authenticated-orcid":false,"given":"Bingrong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical, University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2020.0417"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.077"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-00322-5"},{"issue":"8","key":"e_1_2_13_5_1","first-page":"2153","article-title":"Exploring the Pathogenesis and Mechanism\u2010Targeted Treatments of Rosacea: Previous Understanding and Updates","volume":"11","author":"Chen C.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7181"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106178"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013560"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111636"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248650"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087021"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19449"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14164"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00461-0"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1775871"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.06.063"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002386"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.06.027"},{"issue":"6","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/ddg.13144","article-title":"Physical Modalities for the Treatment of Rosacea","volume":"14","author":"Hofmann M. A.","year":"2016","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.24"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22071"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000888"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-021-02259-2"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2019.1661487"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2164"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12982"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-021-02225-y"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12819"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-54215-2_9"},{"key":"e_1_2_13_32_1","first-page":"323","article-title":"Cutaneous and Ocular Rosacea: Common and Specific Physiopathogenic Mechanisms and Study Models","volume":"27","author":"Rodrigues\u2010Braz D.","year":"2021","journal-title":"Molecular Vision"},{"issue":"1","key":"e_1_2_13_33_1","first-page":"Sr1","article-title":"Hormesis, Epitaxy, the Structure of Liquid Water, and the Science of Homeopathy","volume":"13","author":"Mastrangelo D.","year":"2007","journal-title":"Medical Science Monitor"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051424"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14757"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12121"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.222"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00597-7"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01635-6"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.892"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.141"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14115"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.101121"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22566"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-021-04796-3"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23787"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21677"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj0324"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.01.018"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113292"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-3204"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:09:18Z","timestamp":1786021758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jocd.70727"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70727","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70727"}}