{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:37:50Z","timestamp":1786117070836,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Melasma is an acquired facial hyperpigmentation disorder that disproportionately affects sun\u2010exposed areas. Current treatments show limited efficacy and tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To assess, in a non\u2010controlled prospective pilot trial, the efficacy of a fluid cream SPF 50+ sunscreen containing ellagic acid, niacinamide, and a non\u2010UV\u2010filtering extract of\n                      <jats:italic>Polypodium leucotomos<\/jats:italic>\n                      (PLE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty women (mean age 40\u2009\u00b1\u200910\u2009years) with melasma or sun\u2010induced hyperpigmentation applied the sunscreen every morning and every 2\u2009h during sun exposure for 12\u2009weeks. The primary endpoint was the change in Melasma Area and Severity Index (MASI) at week 12 and week 24 (follow\u2010up). The secondary endpoints were Line\u2010field Confocal Optical Coherence Tomography (LC\u2010OCT) evaluation of pigment distribution and hyper\u2010reflective cells. Local tolerability was also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All subjects completed the study. Baseline MASI (6.9\u2009\u00b1\u20093.2) decreased to 4.4\u2009\u00b1\u20093.3 at week 12 and 3.9\u2009\u00b1\u20093.1 at week 24 (\u221244% from baseline,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001). LC\u2010OCT pigment scores declined from 2.2\u2009\u00b1\u20090.8 to 1.5\u2009\u00b1\u20090.6 at week 24 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and hyper\u2010reflective cells decreased from 47% to 26%. The product was well tolerated, with tolerability scores near to zero.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This pilot proof\u2010of\u2010concept study suggests that an SPF 50+ sunscreen containing ellagic acid, niacinamide, and PLE may reduce melasma severity and improve hyperpigmentation with excellent tolerability. These findings warrant confirmation in larger controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      clinical registration number\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.isrctn.com\/ISRCTN18053239\">ISRCTN18053239<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70732","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:45:09Z","timestamp":1770615909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 50+ Sunscreen Containing\n                    <i>Polypodium Leucotomos<\/i>\n                    Extract, Ellagic Acid, and Niacinamide in Facial Melasma and Photoaging\u2010Related Hyperpigmentation: A Pilot Observational Study Using Line\u2010Field Confocal Optical Coherence Tomography"],"prefix":"10.1111","volume":"25","author":[{"given":"Alessia","family":"Villani","sequence":"first","affiliation":[{"name":"Dermatologia Azienda Ospedaliero Universitaria Federico II \u2013Napoli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Genco","sequence":"additional","affiliation":[{"name":"Dermatologia Azienda Ospedaliero Universitaria Federico II \u2013Napoli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3944-3124","authenticated-orcid":false,"given":"Luigi","family":"Coronella","sequence":"additional","affiliation":[{"name":"Dermatologia Azienda Ospedaliero Universitaria Federico II \u2013Napoli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ventura","sequence":"additional","affiliation":[{"name":"Dermatologia Azienda Ospedaliero Universitaria Federico II \u2013Napoli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-1202","authenticated-orcid":false,"given":"Massimo","family":"Milani","sequence":"additional","affiliation":[{"name":"Cantabria Labs Difa Cooper MD  Caronno Pertusella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Alfano","sequence":"additional","affiliation":[{"name":"Cantabria Labs Difa Cooper MD  Caronno Pertusella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8099-0192","authenticated-orcid":false,"given":"Francesca","family":"Colombo","sequence":"additional","affiliation":[{"name":"Cantabria Labs Difa Cooper MD  Caronno Pertusella 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