{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:38:35Z","timestamp":1786117115149,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Xanthelasma\u2010like periocular plaques are rare adverse reactions following injectable collagen stimulators and may be challenging to manage in cosmetically sensitive areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe a rare xanthelasma\u2010like reaction after polymer\u2010based collagen stimulator (poly\u2010L\u2010lactic acid or poly\u2010D,L\u2010lactic acid) intradermal injection and its management using fractional non\u2010ablative lasers and stem cell\u2010derived conditioned media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>A 49\u2010year\u2010old woman with Fitzpatrick skin type IV developed bilateral infraorbital yellowish plaques (~1\u2009\u00d7\u20092\u2009cm) approximately two weeks after a collagen stimulator injection and presented four months later with persistent lesions, after showing minimal response to a prior 577\u2010nm yellow laser\u00a0treatment performed at another clinic. Our first treatment approach consisted of a fractional 1550\u2010nm erbium glass laser combined with intralesional 0.9% sodium chloride and a short course of oral corticosteroids. A subsequent session incorporated combined fractional 1550\u2010nm erbium glass and 1450\u2010nm diode lasers, followed by intradermal stem cell\u2010derived conditioned media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Partial improvement was observed after the initial treatment. Further improvement was achieved following combination laser therapy with adjunctive stem cell\u2010derived conditioned media, with marked lesion flattening and reduced erythema within two months and sustained improvement at four\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights a rare xanthelasma\u2010like reaction following polymer\u2010based collagen stimulator injection and demonstrates that a staged, non\u2010ablative fractional laser approach with adjunctive stem cell\u2010derived conditioned media\u00a0may be an effective and minimally invasive management option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70739","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:57:41Z","timestamp":1771304261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Xanthelasma\u2010Like Reaction Following Poly\u2010L\u2010Lactic Acid Intradermal Injection Managed With Fractional Non\u2010Ablative Lasers and Stem Cell\u2010Derived Conditioned Media: A Case Report"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-9453","authenticated-orcid":false,"given":"Olivia","family":"Wibisono","sequence":"first","affiliation":[{"name":"Flora House of Beauty Clinic  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0005-8260","authenticated-orcid":false,"given":"Martha","family":"Fang","sequence":"additional","affiliation":[{"name":"Martha Fang Skin Clinic  Bali Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1364","authenticated-orcid":false,"given":"Kyu\u2010Ho","family":"Yi","sequence":"additional","affiliation":[{"name":"Division of Anatomy and Developmental Biology, Department of Oral Biology Yonsei University College of Dentistry  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6887-5960","authenticated-orcid":false,"given":"Irwan","family":"Junawanto","sequence":"additional","affiliation":[{"name":"ERHA Dermatology Clinic  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"276","article-title":"Poly\u2010L\u2010Lactic Acid for the Correction of Facial Atrophy and Contour Defects: Safety and Efficacy","volume":"29","author":"Park K. Y.","year":"2018","journal-title":"Journal of Dermatological Treatment"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"769","article-title":"Efficacy and Safety of Injectable Poly\u2010L\u2010Lactic Acid for Facial Volume Restoration","volume":"36","author":"Narins R. S.","year":"2010","journal-title":"Dermatologic Surgery"},{"key":"e_1_2_13_4_1","first-page":"NP83","article-title":"Xanthelasma\u2010Like Reaction to Collagen\u2010Stimulating Agent Injection of the Lower Eyelids: Case Series","volume":"37","author":"Or L.","year":"2017","journal-title":"Aesthetic Surgery Journal"},{"key":"e_1_2_13_5_1","first-page":"3383","article-title":"Xanthelasma Palpebrarum After Dermal Injection","volume":"20","author":"Sim\u00f5es Pires V.","year":"2021","journal-title":"Journal of Cosmetic Dermatology"},{"key":"e_1_2_13_6_1","first-page":"85","article-title":"Late\u2010Onset Foreign\u2010Body Reaction to Poly\u2010L\u2010Lactic Acid","volume":"47","author":"Jeon Y. J.","year":"2020","journal-title":"Archives of Plastic Surgery"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16575"},{"key":"e_1_2_13_8_1","first-page":"97","article-title":"Current Laser Resurfacing Technologies: Fractional Non\u2010Ablative Mechanism and Dermal Remodeling","volume":"5","author":"Preissig J.","year":"2012","journal-title":"Clinical, Cosmetic and Investigational Dermatology"},{"key":"e_1_2_13_9_1","first-page":"521","article-title":"1550\u2010Nm Non\u2010Ablative Fractional Laser Improves Acne Scarring","volume":"47","author":"Lin M. Y.","year":"2021","journal-title":"Dermatologic Surgery"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.02.019"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04311-8"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:08:58Z","timestamp":1786021738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jocd.70739"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70739","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70739"}}