{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:14:53Z","timestamp":1777958093850,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The new ready\u2010to\u2010use botulinum toxins effectively treat lateral canthal lines; there is still little data on their efficacy in treating glabellar lines. The combined treatment of lateral canthal and glabellar lines allows the eyebrow to be repositioned.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To show the onset and action of RelabotulinumtoxinA on the periocular area, by measuring the variations of the area under the eyebrow in a real\u2010life setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>In this real\u2010life, multi\u2010center case series, 36 patients (30 women, 6 men), aged 30\u201362\u2009years, were treated with RelabotulinumtoxinA in glabellar and lateral canthal areas; patients were treated on day 0 (T0) and followed until day 30. Photos taken at T0 and at all follow\u2010up time points were compared in calculating the median of the palpebral surface.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients responded to the treatment. Most of RelabotulinumtoxinA's effect on eyebrow position (76.25%) was seen within day 2, peaking in the first 24\u2009h. The variation rate sharply declines by day 7. Patients showed a median increase in the exposed eyelid area of +11.91% compared to T0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the real\u2010world setting, RelabotulinumtoxinA showed efficacy in treating GLs and LCLs. In the post\u2010intervention phases (follow\u2010up and potential touch\u2010ups), the fast onset of the ready\u2010to\u2010use product can save time. The palpebral area measurement technique, which was selected to assess objectively the response, may allow for a higher level of precision than measuring distances in the periocular range and can be helpful in this type of study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70745","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:34:57Z","timestamp":1772966097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Objective Assessment of the Onset of\n                    <scp>RelabotulinumtoxinA<\/scp>\n                    in the Elevation of the Eyebrow and Its Clinical Implications"],"prefix":"10.1111","volume":"25","author":[{"given":"Carlo","family":"Di Gregorio","sequence":"first","affiliation":[{"name":"Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivano","family":"Iozzo","sequence":"additional","affiliation":[{"name":"Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Belmontesi","sequence":"additional","affiliation":[{"name":"Centro Clinico Formativo Agor\u00e0 Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Santis","sequence":"additional","affiliation":[{"name":"Lounge Med Clinic  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Leone","sequence":"additional","affiliation":[{"name":"Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6959-4455","authenticated-orcid":false,"given":"Alessandro","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Microsurgery \u2013 Careggi University Hospital  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Picaut","sequence":"additional","affiliation":[{"name":"Verri\u00e8res le Buisson  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-5054","authenticated-orcid":false,"given":"Matteo","family":"Tretti\u2010Clementoni","sequence":"additional","affiliation":[{"name":"Laserplast Srl  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000293"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002119"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjae131"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2021.00003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-022-03018-y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99147.x"},{"key":"e_1_2_12_8_1","volume-title":"Botulinum Toxin Treatment of the Upper Face. 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