{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:14:57Z","timestamp":1777958097444,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is increasing patient demand for improved skin quality and the desire to achieve rejuvenated skin and improve self\u2010confidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this 12\u2010week study was to assess changes in skin quality and subject satisfaction after using a novel anti\u2010aging 10\u2010peptide serum (Pep Up Collagen Boost Face &amp; Neck Serum; Colorescience Inc., Carlsbad, CA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Healthy adult subjects seeking facial and neck skin rejuvenation (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200948) were divided into two groups. Group A included subjects not currently using prescription, medical grade, advanced, or physician\u2010dispensed skincare products and Group B included subjects who currently were using such products. Subjects in both groups applied the anti\u2010aging peptide serum twice daily as part of their daily skincare routine for 12\u2009weeks and were evaluated after 4, 8, and 12\u2009weeks of treatment. Improvements in Global Skin condition and other parameters associated with skin quality were assessed by three investigators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By Week 12, 89.6% of subjects showed clinical improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), with most (52%) achieving moderate\u2010to\u2010marked global improvement. Both groups had median global scores of 3.0, with similar mean scores (Group A, 2.6; Group B, 2.8). Subjects in both groups indicated improvements in global scores (Group A, 91.7%; Group B, 87.5%) and most subjects in both groups demonstrated marked improvements from baseline (54.2% and 50.0%). The product was well\u2010tolerated and subject satisfaction was high.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The twice\u2010daily application of a novel anti\u2010aging 10\u2010peptide serum restores several markers of facial and neck skin quality that were incremental to basic skincare routines and professional skincare regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70746","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:57:57Z","timestamp":1773046677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Open\u2010Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10\u2010Peptide Face and Neck Serum to Address Skin Quality"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6090-3209","authenticated-orcid":false,"given":"Kimberly","family":"Cayce","sequence":"first","affiliation":[{"name":"Cayce Dermatology Center &amp; Medical Spa  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8011-0876","authenticated-orcid":false,"given":"Kristen M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Ooh La La Spa, Anti\u2010Aging &amp; Wellness  Glen Carbon Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6715-818X","authenticated-orcid":false,"given":"Savanna","family":"Boda","sequence":"additional","affiliation":[{"name":"Savanna Boda Aesthetics  Southlake Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-025-03942-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15968"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2019.03.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000234900.26676.0b"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S309374"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16615"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003079"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2005.00286.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15678"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.06.015"},{"key":"e_1_2_11_12_1","first-page":"163","article-title":"Cigarettes Smoking and Skin: A Comparison Study of the Biophysical Properties of Skin in Smokers and Non\u2010Smokers","volume":"18","author":"Yazdanparast T.","year":"2019","journal-title":"Tanaffos"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_1092_20"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S44686"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-025-04021-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029380"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.12.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.204"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38167-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12507"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2009.00490.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12046"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12314"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12671"},{"key":"e_1_2_11_25_1","first-page":"38","article-title":"Immediate and Long\u2010Term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles","volume":"2","author":"Trookman N. 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