{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:49Z","timestamp":1782294529114,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Photodynamic therapy and cryotherapy are treatment options for actinic keratosis; however, their efficacy and safety remain debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To perform a high\u2010quality systematic review and meta\u2010analysis exploring the efficacy and safety of photodynamic therapy and cryotherapy in actinic keratosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was performed applying the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. We searched PubMed, Web of Science, Cochrane, Science Direct, Ovid, EBSCO, Wiley, and Google Scholar for randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of seven studies with 1233 patients were identified. PDT and cryotherapy showed similar success in clearing lesions (RR, 1.02; 95% CI, 0.92\u20131.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74). While both treatments performed comparably on the head and face (RR, 1.10; 95% CI, 0.94\u20131.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.24), data from one trial suggested cryotherapy might be more effective for lesions on the arms and legs (RR, 0.88; 95% CI, 0.82\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, more research is needed to confirm this finding. Cosmetic outcomes were significantly better for PDT (74.62% vs. 49.11%: RR, 1.52; 95% CI, 1.4\u20131.65;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001) than cryotherapy. Similarly, PDT was superior to cryotherapy in patient satisfaction though the overall difference was not statistically significant (RR, 1.43; 95% CI, 0.91\u20132.25;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12). PDT was associated with a significantly higher risk of burning sensations and pain (RR, 1.95; 95% CI, 1.27\u20133.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), whereas cryotherapy more frequently led to vesicles and blisters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lesion clearance may depend on location. It is comparable for head and face lesions, while data from one trial suggests cryotherapy may be better for extremity lesions. PDT is associated with a higher occurrence of pain\/burning, while cryotherapy leads to more vesicles\/blisters. Future research should focus on standardized protocols, including blinded post\u2010treatment assessments to improve reliability and minimize bias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70749","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T08:05:31Z","timestamp":1775894731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7112-9197","authenticated-orcid":false,"given":"Saleh","family":"Aldraibi","sequence":"first","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kholoud","family":"Alzubaidi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Umm Al Qura University  Al Qunfudhah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Turkistani","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmalik Bin","family":"Kassim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhai","family":"Almutairi","sequence":"additional","affiliation":[{"name":"King Khalid General Hospital  Hafer Al Batin Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Alhammadi","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa medical city  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumanah","family":"Makhtoum","sequence":"additional","affiliation":[{"name":"Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Fahad Armed Forces Hospital  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"23","article-title":"Actinic Keratoses: Natural History and Risk of Malignant Transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial","volume":"116","author":"Criscione V. 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