{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:37:40Z","timestamp":1786117060920,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Oily skin is characterized by excessive sebum production and increased activity of\n Cutibacterium acnes<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To evaluate the effects of mandelic acid exfoliation, microneedle mesotherapy with a sebum\u2010regulating ampoule, and combination therapy on skin parameters and\n C. acnes<\/jats:italic>\n activity in women with oily skin.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifty\u2010five women aged 18\u201347 were randomly assigned to three groups: microneedle mesotherapy (6 treatments), mandelic acid exfoliation (6 treatments), or combination therapy (3 exfoliations followed by 3 mesotherapy treatments). Skin hydration, sebum level, pH, and gloss were measured using an MPA Courage&Khazaka device.\n C. acnes<\/jats:italic>\n activity was assessed indirectly by porphyrin fluorescence with a Visiopor device. Measurements were taken on the cheeks and in the T\u2010zone before treatment (day 1), after three session (day 63), and after six sessions (day 126).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Skin hydration increased significantly in all groups. Mesotherapy reduced sebum in the T\u2010zone only after six treatments, while exfoliation reduced sebum mainly on the cheeks. Combination therapy resulted in the most extensive and stable sebum reduction in both areas. A temporary decrease in pH was observed after mesotherapy, with no pH changes after exfoliation or combination therapy. No significant changes in skin gloss were found.\n C. acnes<\/jats:italic>\n colonization increased in the T\u2010zone after mesotherapy, whereas exfoliation and combination therapy significantly reduced all colonization indices, with the strongest effect for combination therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Mandelic acid exfoliation and microneedle mesotherapy support regulation of sebaceous activity and epidermal barrier function. Combination therapy is therapeutically superior, providing optimal improvement in skin parameters and the most effective reduction of\n C. acnes<\/jats:italic>\n activity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70752","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:45:20Z","timestamp":1771566320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and\n Cutibacterium acnes<\/i>\n Colonization in Women With Oily Skin"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-4446","authenticated-orcid":false,"given":"Agnieszka","family":"Ciozda","sequence":"first","affiliation":[{"name":"Doctoral School Medical University of Lublin Lublin Poland"},{"name":"Department of Cosmetology and Aesthetic Medicine Medical 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