{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:47:45Z","timestamp":1790650065167,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy, patient satisfaction, safety profile, and biological impact of Poly\u2010L\u2010lactic acid (PLLA LASYNPRO) over 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicenter study included patients treated with PLLA\u2010LASYNPRO. The primary end\u2010point was the proportion of participants who achieved a reduction of at least 1 point in the Wrinkle\u2010Severity\u2010Rating\u2010Scale (WSRS). Secondary end\u2010points included the proportion of participants achieving at least a 1\u2010point reduction in the Midface\u2010Volume\u2010Deficit\u2010Scale (MFVDS), the degree of patient satisfaction assessed by the Global\u2010Aesthetic\u2010Improvement\u2010Scale (GAIS), treatment\u2010related biological and structural changes, and the incidence of adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six female subjects were enrolled. Right\u2010side treatment success rates increased from 44.4% at month\u20101 to 71.9% at month\u20106 (Cochran's\n                      <jats:italic>Q<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005); left\u2010side rates increased from 44.4% to 68.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). MFVDS\u2010treated\u2010side success increased significantly (44.4% to 65.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). GAIS ratings of \u201cMuch Better\u201d or \u201cBetter\u201d were reported by 66.7% at\u2009month 1 and remained high (65.6% at month\u20106). Ultrasound and elastography imaging confirmed increased tissue density, reduction of the Sub\u2010Epidermal\u2010Low\u2010Echogenic\u2010Band (SLEB), signs of neocollagenesis, and improved viscoelasticity. Serum P1CP levels rose significantly from 134.6\u2009\u00b1\u200998.9\u2009ng\/mL to a peak of 233.2\u2009\u00b1\u2009163.1\u2009ng\/mL at\u2009month 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 vs. baseline), remaining elevated through month 6 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). AEs were limited to mild\u2013moderate, self\u2010resolving inflammation, erythema, edema, and injection\u2010site discomfort; no serious AEs occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PLLA\u2010LASYNPRO achieved significant, sustained improvements in facial wrinkles and volume with high patient satisfaction and biological evidence of collagen stimulation. The treatment demonstrates an excellent safety profile. Further large\u2010scale, randomized trials are recommended to confirm long\u2010term efficacy and define its role in aesthetic practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70753","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:31:17Z","timestamp":1771565477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Outcomes of an Innovative Poly\u2010L\u2010Lactic Acid (LASYNPRO) in Facial Rejuvenation: Prospective, Multicenter Spanish Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-5278","authenticated-orcid":false,"given":"Fernando","family":"Urdiales\u2010G\u00e1lvez","sequence":"first","affiliation":[{"name":"Instituto M\u00e9dico Miramar  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1965-7091","authenticated-orcid":false,"given":"Paula A.","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica ROBEGA  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iratxe","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Iratxe D\u00edaz  Bilbao Vizcaya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u20106041\/8\/6\/065001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2017.05.032"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0445"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14061153"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14221845"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00069.x"},{"issue":"9","key":"e_1_2_12_8_1","first-page":"929","article-title":"Recommendations on the Use of Injectable Poly\u2010L\u2010Lactic Acid for Skin Laxity in Off\u2010Face Areas","volume":"18","author":"Haddad A.","year":"2019","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-024-04098-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200311210-00009"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.08.056"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2008.06.005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646206777689116"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X10391213"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037506"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16635"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-024-04499-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15571"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091320"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32303.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.881"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01419.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.1.97"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","unstructured":"D.Bertossi M.Cavallini A.Camporese et\u00a0al. \u201cFirst Insights on the Upcoming Role of Next\u2010Generation PLLA\u2010LASYNPRO in Aesthetic and Regenerative Medicine. 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