{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:14:45Z","timestamp":1777958085770,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Numerous retinoid\u2010based skincare products are available over\u2010the\u2010counter for photodamaged and photoaged skin, but are associated with objective (e.g., erythema, dryness, flaking, edema) and subjective (e.g., itching, tingling, stinging, burning) tolerability issues. A novel retinal formulation was developed using an engineered biomimetic vegan exosome as a delivery system. The formulation also contains proprietary and potent hyaluronic acid, as well as plant\u2010based actives commonly used in traditional herbal medicines for their anti\u2010inflammatory and antioxidant properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evaluate the efficacy and tolerability of this biomimetic exosome\u2010encapsulated retinal product for treatment of mild\u2010to\u2010moderate facial photodamage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>Twenty females aged 35 to 65\u2009years, with Fitzpatrick skin types I\u2010VI, mild\u2010to\u2010moderate facial fine lines and wrinkles, and mild\u2010to\u2010moderate facial photodamage, were assessed at screening\/baseline and weeks 2, 4, 8, and 12. Investigator\u2010 and participant\u2010assessed evaluations were performed at each visit. The primary objective was to demonstrate a decrease in the appearance of fine lines and wrinkles, erythema, as well as a reduction of overall facial photodamage after a 12\u2010week topical regimen. The secondary objective was to measure the frequency of adverse events throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Statistically significant improvements in erythema, skin tone, skin texture, and lines\/wrinkles were observed at all follow\u2010up visits, compared to baseline. At weeks 8 and 12, all participants (100%) displayed improvements in facial aesthetics. Most participants (19\/20; 95.00%) were satisfied with the product and would recommend it to others. No product\u2010related adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daily use of this \u201chydrating retinal\u201d improved signs of facial photodamage with none to mild signs of skin irritation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70755","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:45:31Z","timestamp":1772959531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Single\u2010Center, Open\u2010Label Study to Evaluate the Efficacy and Tolerability of Retinal Encapsulated in a Novel Biomimetic Exosome in the Treatment of Mild\u2010To\u2010Moderate Facial Photodamage"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael H.","family":"Gold","sequence":"first","affiliation":[{"name":"Gold Skin Care Center and Tennessee Clinical Research Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn M.","family":"Enright","sequence":"additional","affiliation":[{"name":"Klynical Consulting &amp; Services  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glynis","family":"Ablon","sequence":"additional","affiliation":[{"name":"Ablon Skin Institute &amp; Research Center  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Barbarino","sequence":"additional","affiliation":[{"name":"Barbarino Surgical Arts  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suneel","family":"Chilukuri","sequence":"additional","affiliation":[{"name":"Refresh Dermatology  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Day","sequence":"additional","affiliation":[{"name":"Day Dermatology &amp; Aesthetics  New York New York City USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Cosmetic Dermatology &amp; Clinical Research, Schweiger Dermatology Group  New York New York City USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Lain","sequence":"additional","affiliation":[{"name":"Sanova Dermatology  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2963-3858","authenticated-orcid":false,"given":"Ava","family":"Shamban","sequence":"additional","affiliation":[{"name":"AVA MD Medical &amp; Cosmetic Dermatology  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1128-9626","authenticated-orcid":false,"given":"Todd","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Clinical Research Center of the Carolinas  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2006.1.4.327"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200565080\u201000003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010016\u20100185\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7753"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2019.87443"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211035091"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010025\u201000933\u2010z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250\u2010474X.78519"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33378"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5110"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010021\u201000928\u2010x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14237278"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.02.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.865682"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4644"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.03.018"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c01104"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900795"},{"issue":"9","key":"e_1_2_12_20_1","first-page":"33","article-title":"Evidence for the Efficacy of Over\u2010The\u2010Counter Vitamin A Cosmetic Products in the Improvement of Facial Skin Aging: A Systematic Review","volume":"14","author":"Spierings N. 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