{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:00:00Z","timestamp":1787065200360,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exosomes have emerged as a promising therapeutic agent for various dermatological conditions such as acne, atopic dermatitis, and wound healing. This study aims to evaluate exosome's efficacy in improving postoperative scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients underwent revision rhinoplasty with autologous costal cartilage, each with a 3\u2009cm anterior chest incision scar were enrolled. Scars (mean 4.3\u2009months postoperatively) were divided into medial and lateral halves; one half was treated with ASC\u2010Exosome (experimental) and the other with hyaluronic acid (control). Outcomes were assessed using the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The experimental side treated with ASC\u2010Exosome demonstrated improvements compared to the control side. Pigmentation improved significantly in the Observer Scar Assessment Scale (OSAS) group from week 3 onward, though no consistent changes were observed on the VSS. Pliability showed significant improvement in both OSAS and VSS, beginning at week 3 and persisting through week 8. Relief also improved in the OSAS group from weeks 4 to 8. While no vascularity differences were detected, one\u2010year follow\u2010up photographs confirmed superior improvements in scar height and thickness on the exosome\u2010treated side. Patient Scar Assessment Scale (PSAS) indicated significant improvements in scar color by week 4, stiffness by week 3, and thickness by week 2. Irregularity showed significant differences at week 4 and week 8. No significant differences were noted in pain or itching between the sides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exosomes significantly improved scar quality, particularly pigmentation, pliability, and relief, and can represent a valuable option for postoperative scar management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70756","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:17:00Z","timestamp":1773015420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Split\u2010Scar Study: Study of Surgical Scar Using Exosomes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4088-1379","authenticated-orcid":false,"given":"Kyung Hwan","family":"Jeong","sequence":"first","affiliation":[{"name":"C.LILY Facial Rejuvenation Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-1754","authenticated-orcid":false,"given":"Kui Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University, College of Medicine, Chung\u2010Ang University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-9837","authenticated-orcid":false,"given":"Dong\u2010Woo","family":"Jung","sequence":"additional","affiliation":[{"name":"Honesty Plastic Surgery Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12472"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"20","article-title":"Regulation of Transforming Growth Factor \u03b21, Platelet\u2010Derived Growth Factor, and Basic Fibroblast Growth Factor by Silicone Gel Sheeting in Early\u2010Stage Scarring","volume":"42","author":"Choi J.","year":"2014","journal-title":"Archives of Plastic Surgery"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006064"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325646"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030711"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.5.615"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000547415.38888.c4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.4.163"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001887"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081698"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2024.2426626"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010148"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400609"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.11.026"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.92897"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02783-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15872"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0939-5"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3666"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.606"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010036"},{"issue":"6","key":"e_1_2_12_24_1","first-page":"477","article-title":"Synthesis and Physiological Implications of Melanic Pigments \u2010 Review","volume":"21","author":"Bhawan J.","year":"2008","journal-title":"Pigment Cell & Melanoma Research"},{"issue":"1","key":"e_1_2_12_25_1","first-page":"1","article-title":"Skin Brightening Efficacy of Exosomes Derived From Adipose\u2010Derived Stem Cells","volume":"19","author":"Park H.","year":"2020","journal-title":"Journal of Cosmetic Dermatology"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.09.066"},{"issue":"7","key":"e_1_2_12_27_1","first-page":"12S","article-title":"The Basic Science of Wound Healing","volume":"117","author":"Gurtner G. C.","year":"2006","journal-title":"Plastic and Reconstructive Surgery"},{"issue":"1","key":"e_1_2_12_28_1","first-page":"46","article-title":"The Content and Ratio of Type I and III Collagen in Skin Differ With Age and Injury","volume":"63","author":"Griffiths C. E.","year":"2010","journal-title":"Journal of Plastic, Reconstructive & Aesthetic Surgery"},{"issue":"5","key":"e_1_2_12_29_1","first-page":"e129","article-title":"Correlation Between Collagen Type I \u2010 III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction With the Round Block Technique After Breast\u2010Conserving Surgery","volume":"65","author":"Stijn J.","year":"2012","journal-title":"Journal of Plastic, Reconstructive & Aesthetic Surgery"},{"issue":"8","key":"e_1_2_12_30_1","article-title":"Adipose Tissue\u2010Derived Mesenchymal Stem Cell\u2010Derived Exosomes Promote Wound Healing and Tissue Regeneration","volume":"21","author":"Zhang Y.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310434"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2019.05.005"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.01.034"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S542022"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318278906d"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14856"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:51:40Z","timestamp":1777956700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jocd.70756"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70756","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70756"}}