{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:02:04Z","timestamp":1791270124112,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010acne scarring is a prevalent dermatological concern with significant impact on quality of life. Fractional CO2 laser (FCL) and microneedling radiofrequency (MNRF) are widely used treatments, but their comparative efficacy and safety require further synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives<\/jats:title>\n                    <jats:p>This meta\u2010analysis was conducted to compare the efficacy and safety of FCL versus MNRF in the management of post\u2010acne scarring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The analysis included eight randomized controlled trials involving a total of 249 patients. The primary outcomes evaluated encompassed improvement in acne scars, patient satisfaction scores, pain levels, the risk of post\u2010inflammatory hyperpigmentation, and the duration of erythema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FCL demonstrated superior improvement in acne scars (MD: 0.31, 95% CI, 0.13\u20130.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005) and higher patient satisfaction (MD: 0.32, 95% CI, 0.10\u20130.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) compared to MNRF. However, FCL was associated with significantly higher pain scores (MD: 2.14, 95% CI, 1.90\u20132.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), an increased risk of PIH (RR: 4.44, 95% CI, 2.39\u20138.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), and a longer duration of erythema (MD: 1.72\u2009days, 95% CI, 1.43\u20132.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). MNRF exhibited a more favorable safety profile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While FCL offers superior efficacy for post\u2010acne scarring, MNRF provides better tolerability. The choice of treatment should be individualized, considering patient\u2010specific factors such as skin type, pain tolerance, and recovery expectations. Further research with longer follow\u2010up and standardized outcomes is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70765","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:45:20Z","timestamp":1773377120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fractional\n                    <scp>CO2<\/scp>\n                    Laser Versus Micro Needling Radiofrequency for Post Acne Scarring: A Meta\u2010Analysis of\n                    <scp>RCTs<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-5372","authenticated-orcid":false,"given":"Yahya","family":"Argobi","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Tobeigei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris I.","family":"Alasiri","sequence":"additional","affiliation":[{"name":"Security Forces Hospitals Program General Directorate of Medical Services, Ministry of Interior  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702493"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62715-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_154_19"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_177_19"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S267192"},{"issue":"2","key":"e_1_2_12_8_1","first-page":"56","article-title":"Evaluation of Fractional CO 2 Laser Efficacy in Acne Scar","volume":"3","author":"Saryazdi S.","year":"2012","journal-title":"Journal of Lasers in Medical Sciences"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14539"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002020"},{"key":"e_1_2_12_11_1","unstructured":"D.Nikhita \u201cA Comparative Study of Efficacy of Resurfacing with Fractional CO2 Laser Versus Dermaroller in the Treatment of Post Acne Scars (Doctoral dissertation Rajiv Gandhi University of Health Sciences) \u201d (2018)."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12909"},{"issue":"3","key":"e_1_2_12_13_1","first-page":"336","article-title":"Efficacy of Micro\u2010Needling on Post Acne Scars","volume":"31","author":"Khalid F. A.","year":"2019","journal-title":"Journal of Ayub Medical College, Abbottabad"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0358-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05029.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.21608\/bjas.2024.314744.1476"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_65_19"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23655"},{"issue":"2","key":"e_1_2_12_19_1","first-page":"91","article-title":"Efficacy and Safety of Microneedling With and Without Platelet\u2010Rich Plasma Versus Fractional CO2 Laser for Treatment of Acne Scars: A Randomized Clinical Trial","volume":"25","author":"Behrangi E.","year":"2022","journal-title":"Iranian Journal of Dermatology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nepr.2021.103194"},{"issue":"12","key":"e_1_2_12_22_1","article-title":"Why the Cochrane Risk of Bias Tool Should Not Include Funding Source as a Standard Item","volume":"2013","author":"Sterne J. A. C.","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000429"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.43611"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.720023"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.25259\/jcas_122_23"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.51253\/pafmj.v71i6.5444"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijced.2021.009"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-70"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15348"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-022-02845-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S502295"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002972"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:50:14Z","timestamp":1777956614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jocd.70765"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70765","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70765"}}