{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:52:06Z","timestamp":1783630326188,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the value of non\u2010invasive skin detection techniques for the therapeutic assessment of moderate\u2010to\u2010severe acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we collected patients with moderate\u2010to\u2010severe acne vulgaris who attended the Department of Dermatology at the First\u00a0Affiliated Hospital of Guilin Medical University between October 2021 and December 2022, and analyzed their high\u2010frequency ultrasound (HFUS) and color Doppler flow imaging (CDFI) characteristics at the Weekend 0 (T0), Weekend 4 (T1), and Weekend 12 (T2) of their treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 30 patients with moderate\u2010to\u2010severe acne vulgaris [mean age 21.1\u2009\u00b1\u20093.4\u2009years; 14 males (46.7%), 16 females (53.3%)] were enrolled. HFUS assessment revealed improvements (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in multiple parameters following treatment. Prior to treatment, there was perfect agreement (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20091.0) between the Pillsbury clinical grading and the SSSA ultrasound grading in all 30 patients (100%). Among the 30 patients who completed the 12\u2010week follow\u2010up, post\u2010treatment ultrasound grading was higher than the clinical Pillsbury grading in 17 cases (56.7%). Agreement between the two grading methods post\u2010treatment was poor (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.645, 95% CI: \u22120.17, 0.77), though statistical significance was limited by sample size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HFUS effectively visualizes deep acne lesions (nodules\/cysts). Although ultrasound grading demonstrates slower severity reduction than clinical assessment, it provides more objective severity evaluation. CDFI enhances hemodynamic analysis through real\u2010time flow visualization. Combined HFUS\/CDFI enables enhanced severity and prognostic assessment in moderate\u2010to\u2010severe acne vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70793","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:22:06Z","timestamp":1775020926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Value of High\u2010Frequency Ultrasound and Color Doppler Flow Imaging in Assessing the Efficacy of Moderate\u2010to\u2010Severe Acne Vulgaris: A Prospective Single\u2010Arm Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1755-2061","authenticated-orcid":false,"given":"Litao","family":"Zheng","sequence":"first","affiliation":[{"name":"Center of Burns and Plastic Surgery and Dermatology The 924th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army (PLA)  Guilin China"},{"name":"Department of Dermatology The First Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Guilin Medical University  Guilin China"},{"name":"Department of Dermatology The First People's Hospital of Yulin  Yulin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Ali","sequence":"additional","affiliation":[{"name":"School of International Education Guilin Medical University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Guilin Medical University  Guilin 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