{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:31:43Z","timestamp":1790271103302,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chemotherapy\u2010induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for routine clinical use. Keratinocyte growth factor (KGF) has been shown to have cytoprotective effects on human hair follicles and reduce alopecia in preclinical models. We hypothesized that KGF\u2010hair serum (KGF\u2010HS) will prevent CIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a Simon two\u2010stage, single\u2010arm clinical study in women with early\u2010stage breast cancer (ESBC) scheduled to receive at least four cycles of chemotherapy. The primary outcome was preservation of hair after chemotherapy, whereas secondary measures included patient\u2010reported wig use, comfort, and validated quality\u2010of\u2010life instruments (EORTC QLQ\u2010C30, HADS, and BIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty patients were evaluable for the primary end point. None achieved meaningful hair preservation. The average duration of treatment of KGF\u2010HS application was 4.6\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study of women with ESBC receiving chemotherapy, using the KGF\u2010HS did not prevent CIA. There was no statistical difference pre\u2010 and post\u2010study BIS, HADS, and EORTC\u201030 scores. Application of the KGF\u2010HS was reported to be easy, with minimal discomfort, and a non\u2010oily appearance. Patients' ease of use and acceptability of a topical agent for CIA further supports the development of new agents for a more practical and affordable alternative to scalp cooling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      : NCT04554732\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70797","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:36:42Z","timestamp":1773653802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor\u2010Hair Serum for the Prevention of Chemotherapy\u2010Induced Alopecia"],"prefix":"10.1111","volume":"25","author":[{"given":"Katherine","family":"Mann","sequence":"first","affiliation":[{"name":"George Washington School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethika","family":"Potluri","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"Paul","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center  Tucson Arizona USA"},{"name":"Banner University Medical Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Segar","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center  Tucson Arizona USA"},{"name":"Banner University Medical Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Ehsani","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center  Tucson Arizona USA"},{"name":"Banner University Medical Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Roe","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavani","family":"Chalasani","sequence":"additional","affiliation":[{"name":"George Washington School of Medicine and Health Sciences  Washington DC USA"},{"name":"University of Arizona Cancer Center  Tucson Arizona USA"},{"name":"Banner University Medical Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"5","article-title":"Chemotherapy\u2010Induced Hair Loss","volume":"15","author":"Trueb R. M.","year":"2010","journal-title":"Skin Therapy Letter"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1188\/17.CJON.226\u2010233"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.593"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20939"},{"key":"e_1_2_10_6_1","unstructured":"J.Uscher \u201cCold Caps and Scalp Cooling Systems \u201d Breastcancer.org https:\/\/www.breastcancer.org\/treatment\u2010side\u2010effects\/hair\u2010loss\/cold\u2010caps\u2010scalp\u2010cooling#:~:text=Covering%20the%20cost%20of%20scalp%20cooling \u2010Advertisement&text=Cold%20caps%20typically%20cost%20about a%20full%20course%20of%20chemotherapy."},{"issue":"1","key":"e_1_2_10_7_1","first-page":"145","article-title":"Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation: Normalization of the Nu\/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy\u2010Induced Alopecia","volume":"147","author":"Danilenko D. M.","year":"1995","journal-title":"American Journal of Pathology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65402-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14421"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14844"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201006005\u20106"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28961"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30040275"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:51:27Z","timestamp":1777956687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jocd.70797"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70797","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70797"}}