{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:10:03Z","timestamp":1783721403718,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Xerosis cutis is a common skin condition characterized by dryness, scaling, and pruritus due to impaired barrier function and reduced natural moisturizing factors. This study aimed to evaluate the clinical efficacy of a 10% urea lotion in adults with xerosis and assess participant satisfaction with the product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective, single\u2010arm clinical study was conducted over 60\u2009days in adults with confirmed xerosis. Participants applied a 10% urea lotion with Prolom thermal water twice daily. Skin hydration and elasticity were measured by corneometry and cutometry at baseline, day 14, day 30, and day 60. Subjective outcomes were assessed using a product satisfaction questionnaire and the Skindex\u201016 scale. Data were analyzed using repeated measures ANOVA with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant improvements were observed in skin hydration (+55.3%) and elasticity (+55%), as well as reductions in redness, scaling, and itching (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Skindex\u201016 total scores improved by 61%, reflecting enhanced quality of life. The lotion was well tolerated, with no significant adverse effects, and participants reported high satisfaction and willingness to continue use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 10% urea lotion with Prolom thermal water demonstrated significant clinical efficacy in improving hydration, elasticity, and overall skin condition in adults with xerosis over a 60\u2010day period. The treatment was well tolerated and associated with high patient satisfaction and a marked improvement in quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70801","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:39:11Z","timestamp":1773200351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of a 10% Urea Lotion for Xerosis: Clinical and Patient\u2010Reported Outcomes From a Prospective Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8592-0685","authenticated-orcid":false,"given":"Nemanja","family":"Maletin","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Novi Sad  Novi Sad Serbia"},{"name":"Clinic of Internal Oncology Oncology Institute of Vojvodina  Sremska Kamenica Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Spasi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Dermatovenerology University Clinical Center of Vojvodina  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Golu\u0161in","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad  Novi Sad Serbia"},{"name":"Clinic for Dermatovenerology University Clinical Center of Vojvodina  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Bini\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Dermatovenerology University Clinical Center Ni\u0161  Ni\u0161 Serbia"},{"name":"Department of Dermatovenerology, Medical Faculty University of Ni\u0161  Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"Ni\u0161avi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad  Novi Sad Serbia"},{"name":"Clinic for Dermatovenerology University Clinical Center of Vojvodina  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Ran\u0111elovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Dermatovenerology University Clinical Center of Vojvodina  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0161a","family":"Golubovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Dermatovenerology University Clinical Center Ni\u0161  Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Borocki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazar","family":"Marin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-990X","authenticated-orcid":false,"given":"Iva","family":"Bini\u0107","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical Faculty University of Ni\u0161  Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Denda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad  Novi Sad Serbia"},{"name":"Clinic for Eye Diseases University Clinical Center of Vojvodina  Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13906"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.038"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.07.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1970704"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.03.001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2494.2000.00001.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00611-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12690"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5070\/D31911020392"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/2025"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13137"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb08190.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2010.00476.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14093"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160550"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000549265"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.04.022"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540100500202"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"1","article-title":"Final Report of the Safety Assessment of Urea","volume":"24","author":"Andersen F.","year":"2005","journal-title":"International Journal of Toxicology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13740"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600885"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12665-021-09985-w"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2018.05.005"},{"issue":"1","key":"e_1_2_12_25_1","first-page":"22","article-title":"Balneotherapy of Psoriasis","volume":"6","author":"Golu\u0161in Z.","year":"2014","journal-title":"Serbian Journal of Dermatology and Venereology"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-018-7003-7"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-017-0190-9"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70801","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:50:59Z","timestamp":1777956659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jocd.70801"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70801","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70801"}}