{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:00:41Z","timestamp":1781319641014,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the effectiveness and tolerability of a serum comprised of plant\u2010based adaptogens (MYS\u2010REV) for visible improvements in skin changes caused by hormonal fluctuations associated with perimenopause and postmenopause in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Designs<\/jats:title>\n                    <jats:p>A 16\u2010week open\u2010label multicenter study evaluated the efficacy and tolerability of twice\u2010daily application of MYS\u2010REV in females, aged \u2265\u200946\u2009years, Fitzpatrick skin type (FST) I\u2013VI, with fine\u2010to\u2010moderate depth lines and wrinkles, mild\u2010to\u2010moderate elastosis, and crepey skin. Investigators assessed improvements in depth and number of lines\/wrinkles, elastosis, and crepey skin. Additionally, investigators assessed improvements in appearance of skin dullness, skin roughness\/texture, erythema, uneven pigmentation, and pore size, along with objective changes in skin hydration and transepidermal water loss (TEWL), all over 16\u2009weeks. Tolerability and subject self\u2010assessment were assessed over 16\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 16\u2009weeks, twice\u2010daily use of MYS\u2010REV demonstrated mean percent improvements in elastosis\/crepey skin, lines\/wrinkles, skin hydration, and TEWL, and in erythema, dullness, texture\/roughness, pore size, and uneven pigmentation (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). All AEs were mild with no study discontinuations owing to any AE. Subjects reported high levels of satisfaction with MYS\u2010REV beginning as early as 4\u2009weeks and continuing through Week 16.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that twice\u2010daily application of MYS\u2010REV visibly improves skin affected by menopause\u2010related hormonal fluctuations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70802","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:04:28Z","timestamp":1778576668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multicenter Trial of an Enhanced Serum Comprised of 13 Plant\u2010Based Adaptogens Targeting Skin Quality in Females Impacted by Hormonal Decline"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-7415","authenticated-orcid":false,"given":"Zoe D.","family":"Draelos","sequence":"first","affiliation":[{"name":"Dermatology Consulting Services PLLC  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Moradi","sequence":"additional","affiliation":[{"name":"Moradi MD, Cosmetic Surgery  Vista California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4786-2496","authenticated-orcid":false,"given":"Amber","family":"Smathers","sequence":"additional","affiliation":[{"name":"Skinbetter science, Dermatological Beauty Brand of L'Or\u00e9al USA Inc.  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Society for Women's Health Research \u201cMenopause Disparities: Prevalence and Health Impact Across the United States \u201d(2024) https:\/\/swhr.org\/wp\u2010content\/uploads\/2024\/03\/swhr_factsheet_menopause_rev_0222\u20101.pdf."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-024-10145-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00468-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26095-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.23872"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S333663"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S395256"},{"issue":"2","key":"e_1_2_12_9_1","first-page":"15","article-title":"A Multicenter Trial Evaluating a Serum Comprised of Plant\u2010Based Adaptogens Targeting Skin Quality","volume":"17","author":"Draelos Z. D.","year":"2024","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"4","key":"e_1_2_12_10_1","first-page":"53","article-title":"Evaluation of a New, Advanced Antioxidant Containing Topical Allyl Pyrroloquinoline Quinone: Analysis of Antioxidant Properties and Visible Effects in Subjects With Facial Photodamage","volume":"16","author":"Draelos Z. 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