{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:14:42Z","timestamp":1777958082022,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Keloids are benign fibroproliferative tumors that often recur after surgical excision. Combining surgery with postoperative radiotherapy has emerged as a potential treatment strategy, though optimal radiotherapy protocols remain debated.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to preliminarily evaluate the efficacy and safety of a single high\u2010dose brachytherapy session administered within 8\u2009h after surgical excision in keloid\u2010prone patients in a retrospective setting.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective case series analysis was conducted on 32 patients who underwent surgical excision of keloids followed by a single 8\u2009Gy Ir\u2010192 brachytherapy session within 8\u2009h postoperatively. Treatment outcomes and adverse reactions were assessed over a 1\u2010year follow\u2010up period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among the 32 patients, 25 were cured, 5 showed significant improvement, and 2 were ineffective, yielding a total effective rate of 93.75%. No severe radiation\u2010induced skin reactions (Grade III\/IV) or abnormalities in thyroid or estrogen levels were observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this small retrospective series, single\u2010dose 8\u2009Gy brachytherapy administered within 8\u2009h after surgical excision was associated with a high response rate and no severe adverse events. These findings suggest it may be a potentially useful outpatient treatment option for keloids, though further comparative studies are needed to confirm its efficacy and safety.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70804","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:38:11Z","timestamp":1773988691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of Brachytherapy in Postoperative Treatment of Keloid\u2010Prone Patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-7174","authenticated-orcid":false,"given":"Hanhan","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Huai'an, Nanjing Medical University Huaian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Huai'an, Nanjing Medical University Huaian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6588-6097","authenticated-orcid":false,"given":"Changhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Huai'an, Nanjing Medical University Huaian Jiangsu 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of the Efficacy of Resveratrol Treatment in Patients With Scarred Uterus","volume":"15","author":"Ma H.","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"3","key":"e_1_2_10_13_1","first-page":"280","article-title":"Outcomes of Surgical Excision and Brachytherapy in Intractable Keloids","volume":"6","author":"Taheri A.","year":"2017","journal-title":"World Journal of Plastic Surgery"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_186_20"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83255-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003903"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"547","article-title":"Postoperative Electron\u2010Beam Irradiation Therapy for Keloids and Hypertrophic Scars: Retrospective Study of 147 Cases Followed for More Than 18 Months","volume":"111","author":"Ogawa R.","year":"2003","journal-title":"Plastic and 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