{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:56Z","timestamp":1790938076508,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      A novel hyaluronic acid (HA) injectable (Restylane Shaype, HA\n                      <jats:sub>SHA<\/jats:sub>\n                      ) with high strength\/firmness and enhanced HA concentration, optimized for lower face shaping has been developed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This prospective, 8\u2010week, multicenter, post\u2010market study evaluated three treatment algorithms, i.e., the Shayping Technique, for subjects with multiple aesthetic needs, including HA\n                      <jats:sub>SHA<\/jats:sub>\n                      for chin augmentation alone\/in combination with treatments for the lower face and midface with HA\n                      <jats:sub>DEF<\/jats:sub>\n                      (Restylane Defyne) and HA\n                      <jats:sub>LYF<\/jats:sub>\n                      (Restylane Lyft Lidocaine).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Subjects \u2265\u200918\u2009years were assigned to one of the following treatments: Group 1: HA\n                      <jats:sub>SHA<\/jats:sub>\n                      (chin); Group 2: HA\n                      <jats:sub>SHA<\/jats:sub>\n                      (chin) and HA\n                      <jats:sub>DEF<\/jats:sub>\n                      (marionette line areas laterally to the chin); Group 3: HA\n                      <jats:sub>SHA<\/jats:sub>\n                      (chin), HA\n                      <jats:sub>DEF<\/jats:sub>\n                      (marionette line areas laterally to the chin), and HA\n                      <jats:sub>LYF<\/jats:sub>\n                      (midface and\/or nasolabial fold [NLF, piriform fossa] and\/or jawline). Assessments included Global Aesthetic Improvement Scale (GAIS), subject and investigator satisfaction, and collection of adverse events (AEs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The GAIS responder rate (\u201cimproved,\u201d \u201cmuch improved,\u201d or \u201cvery much improved\u201d) was 100% in all groups at Week 8 (primary endpoint) and Week 4 as assessed by the investigator and by subject self\u2010assessment at Weeks 4 and 8. Overall subject and investigator satisfaction with treatment was high, and the safety profile for all product combinations was favorable, with no unexpected AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Treatment with HA\n                      <jats:sub>SHA<\/jats:sub>\n                      for chin augmentation alone\/in combination with HA\n                      <jats:sub>DEF<\/jats:sub>\n                      and HA\n                      <jats:sub>LYF<\/jats:sub>\n                      for comprehensive lower face and midface lift was safe and effective, with 100% aesthetic improvement at 8\u2009weeks post\u2010injection. The Shayping Technique provides standardized guidance for practitioners to perform safe injections and achieve optimal aesthetic outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70807","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:02:06Z","timestamp":1775044926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The\n                    <scp>ARTIST<\/scp>\n                    Post\u2010Market Study: Evaluating a High G' Hyaluronic Acid (\n                    <scp>HA<\/scp>\n                    ) Injectable for Chin Combined With Midface\n                    <scp>HA<\/scp>\n                    Filler Treatments"],"prefix":"10.1111","volume":"25","author":[{"given":"Andreas","family":"Nikolis","sequence":"first","affiliation":[{"name":"Victoria Park Medispas  Montreal Quebec Canada"},{"name":"Division of Plastic Surgery McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K.","family":"Rivers","sequence":"additional","affiliation":[{"name":"Pacific Derm  Vancouver British Columbia Canada"},{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Rosen","sequence":"additional","affiliation":[{"name":"Dermetics Cosmetic Dermatology  Burlington Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Galderma  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Prygova","sequence":"additional","affiliation":[{"name":"Galderma  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torun","family":"Brom\u00e9e","sequence":"additional","affiliation":[{"name":"Galderma  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Restylane Shaype IFU CANADA accessed June 20 2025 https:\/\/www.galderma.com\/sites\/default\/files\/2025\u201003\/90\u201074745\u201001_IFU_Restylane_Shaype\u20102023.pdf."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8145"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8593"},{"key":"e_1_2_11_5_1","unstructured":"Restylane Defyne IFU Canada accessed June 20 2025 https:\/\/www.galdermaaesthetics.com\/ca\/sites\/default\/files\/2022\u201004\/Restylane%20Defyne.pdf."},{"key":"e_1_2_11_6_1","unstructured":"Restylane Lyft Lidocaine IFU Canada accessed June 20 2025 https:\/\/www.galdermaaesthetics.com\/ca\/sites\/default\/files\/2022\u201004\/Restylane%20Lyft.pdf."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010023\u201003812\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14914"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009733"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001424"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15286"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009732"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70807","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:23:24Z","timestamp":1782293004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jocd.70807"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70807","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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