{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:38:10Z","timestamp":1784770690073,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/4585\/2025"],"award-info":[{"award-number":["UID\/4585\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most commercially available botulinum toxin A (BoNT\u2010A) formulations are lyophilized or vacuum\u2010dried powders requiring reconstitution. Recently a ready\u2010to\u2010use formulation (RTUaboBoNT\u2010A) has been introduced. Although its efficacy in reducing glabellar lines has been reported, comparative data with powder onabotulinumtoxinA (OnaBoNT\u2010A) remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy, durability, and safety of RTUaboBoNT\u2010A compared with OnaBoNT\u2010A for moderate to severe glabellar wrinkles:<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty women (25\u201350\u2009years) were randomly allocated to receive either OnaBoNT\u2010A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) or RTUaboBoNT\u2010A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) at equivalent doses in the procerus and corrugator muscles. Outcomes included Electromyography activity (EMG), Merz 5\u2010point glabellar lines scale, FACE\u2010Q satisfaction scores, perceived age and pain intensity (VAS). Assessments were performed at baseline and 1, 2\u2010, 3\u2010, 4\u2010 and 5\u2010months post\u2010injection. Statistical analysis included two\u2010way repeated\u2010measures ANOVA with Bonferroni's post hoc, chi\u2010squared tests and independent Student's t\u2010tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant intergroup differences were observed in EMG activity of the assessed muscles across follow\u2010ups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Glabellar lines severity was comparable between groups at rest and maximum contraction throughout the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Higher satisfaction scores were observed at 2\u2010months in the OnaBoNT\u2010A group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Pain during injection was greater with RTUaboBoNT\u2010A (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). No intergroup differences were found in perceived age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The RTUaboBoNT\u2010A demonstrated similar efficacy, durability, and safety profile to OnaBoNT\u2010A for the treatment of glabellar lines. With minor differences in satisfaction and injection disconfort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70816","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:42:00Z","timestamp":1774590120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Ready\u2010To\u2010Use AbobotulinumtoxinA More Effective Than OnabotulinumtoxinA for Glabellar Lines? A Randomized, Controlled, Triple\u2010Blinded Clinical Trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Jacqueline Rosa","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Figueiredo","family":"Valesan","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia Laureano Navarro","family":"Shishido","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Sanchez\u2010Ayala","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Ponta Grossa  Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Dentistry Sao Leopoldo Mandic University  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-121X","authenticated-orcid":false,"given":"Mariana Barbosa","family":"C\u00e2mara\u2010Souza","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-342X","authenticated-orcid":false,"given":"Giancarlo","family":"De la Torre Canales","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Paran\u00e1 Brazil"},{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM); Egas Moniz School of Health &amp; Science  Caparica, Almada Portugal"},{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine Karolinska  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(95)00152-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0003\u2010066x.48.4.384"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70508"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11592100\u2010000000000\u201000000"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010025\u201005550\u2010z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002491"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac253"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2015.07.003"},{"key":"e_1_2_11_10_1","unstructured":"ISAPS \u201cInternational Survey on Esthetic\/Cosmetic Procedures Performed \u201d(2024) https:\/\/www.isaps.org\/media\/razfvmsk\/isaps\u2010global\u2010survey\u20102024.pdf."},{"issue":"2","key":"e_1_2_11_11_1","first-page":"31","article-title":"Comparison and Overview of Currently Available Neurotoxins","volume":"7","author":"Walker T. J.","year":"2014","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/psn.0000000000000121"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2006.32339.x"},{"key":"e_1_2_11_14_1","unstructured":"Alluzience \u201cAlluzience 200 Speywood Units\/ml Solution for Injection \u2013 ENG SmPC \u201dhttps:\/\/www.lakemedelsverket.se\/sv\/sok\u2010lakemedelsfakta\/lakemedel?id=20191122000079."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw272"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz00"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz248"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16359"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70308"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad222"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14728"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2010.514920"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.12.001"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101725168"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0018"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X13510170"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101647"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab329"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70403"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.iio.0000167237.493"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2232"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2007.34008.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.011"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:22:13Z","timestamp":1782292933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jocd.70816"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70816","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70816"}}