{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:17Z","timestamp":1782294497246,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hair loss is a common condition affecting both men and women, with significant psychosocial impact. While oral supplements are marketed to improve hair growth, their clinical efficacy remains debated. This systematic review aimed to evaluate the effectiveness and safety of commercial oral nutraceuticals for hair growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For this systematic review, a comprehensive search was undertaken in PubMed, Embase, Cochrane CENTRAL, and Web of Science. Eligible studies included randomized controlled trials (RCTs), open\u2010label trials, and proof\u2010of\u2010concept studies evaluating oral supplements in adults (\u2265\u200918\u2009years) with alopecia or hair thinning. Primary outcomes included objective measures including hair counts, density, growth rate, tensile strength, and pull test. Secondary outcomes were investigator\/patient assessments and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14 studies, including 967 participants, were included. Supplements assessed included Ceramosides, Nutrafol, Nourkrin, Lambdapil, Viviscal, Forti5, GFM oral supplement, and Cynatine HNS. Most trials were RCTs with durations of 12\u2009weeks to 12\u2009months. Meta\u2010analysis demonstrated significant improvements with oral supplements versus placebo: reduced telogen hair density (mean difference [MD] \u22125.91, 95% confidence interval [CI] \u22126.74 to \u22125.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), increased anagen hair density (MD 10.48, 95% CI: 8.81 to 12.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), and reduced telogen proportion (MD 3.08, 95% CI: \u22123.35 to \u22122.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). Similarly, significant differences were observed regarding anagen proportion, elongation, and hairs extracted on a pull test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001 for all). Total hair count showed no significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06). Patient\u2010reported outcomes consistently favored supplements, reporting improved thickness, reduced shedding, and better satisfaction. Adverse events were minimal, and safety profiles were favorable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, supplements show promising preliminary results, but more rigorous, independent research is needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70817","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:39:56Z","timestamp":1775727596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Effectiveness of Commercial Oral Supplements for Hair Growth: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7426-3209","authenticated-orcid":false,"given":"Razan","family":"Alanazi","sequence":"first","affiliation":[{"name":"College of Medicine University of Hail  Hail Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadan","family":"Alshammari","sequence":"additional","affiliation":[{"name":"College of Medicine University of Hail  Hail Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadi","family":"Aldossari","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raneem","family":"Alwatban","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deema","family":"Aljeribah","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoog","family":"Alanazi","sequence":"additional","affiliation":[{"name":"College of Medicine University of Hail  Hail Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Alsalhi","sequence":"additional","affiliation":[{"name":"Dermatology Consultant, Department of Dermatology University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-6343","authenticated-orcid":false,"given":"Aminah","family":"Alhumam","sequence":"additional","affiliation":[{"name":"College of Medicine King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajeed","family":"Alajlan","sequence":"additional","affiliation":[{"name":"Professor, Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2025.020"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14983"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0319040"},{"key":"e_1_2_12_5_1","volume-title":"Telogen Effluvium","author":"Hughes E. C.","year":"2025"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"E228","article-title":"An Overview of the Genetic Aspects of Hair Loss and Its Connection With Nutrition","volume":"63","author":"Gokce N.","year":"2022","journal-title":"Journal of Preventive Medicine and Hygiene"},{"issue":"11","key":"e_1_2_12_7_1","first-page":"34","article-title":"A Randomized, Placebo\u2010Controlled Clinical Study Evaluating a Dietary Supplement for Hair Growth","volume":"17","author":"Martin\u2010Biggers J.","year":"2024","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"1","key":"e_1_2_12_8_1","first-page":"S4","article-title":"Natural Hair Supplements: Trends and Myths Untangled","volume":"16","author":"Farris P.","year":"2023","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2023.07.008"},{"issue":"3","key":"e_1_2_12_10_1","first-page":"26","article-title":"Nutraceuticals for Androgenetic Alopecia","volume":"15","author":"Ring C.","year":"2022","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"11","key":"e_1_2_12_11_1","first-page":"s141","article-title":"A Novel Multi\u2010Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals","volume":"16","author":"Farris P. K.","year":"2017","journal-title":"Journal of Drugs in Dermatology : JDD"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0701a01"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04286-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-018-0278-6"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12127"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.22.027"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531890"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S398950"},{"issue":"10","key":"e_1_2_12_19_1","article-title":"Efficacy of Platelet\u2010Rich Plasma as an Adjunct to Hair Transplantation: A Systematic Review","volume":"17","author":"Sindhusen S.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.4867"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-015-0249-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006059202000601"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12929"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16778"},{"issue":"1","key":"e_1_2_12_27_1","first-page":"27","article-title":"Oral Supplementation With l\u2010Cystine, Serenoa Repens, Cucurbita Pepo, and Pygeum Africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double\u2010Blind, Placebo\u2010Controlled, Randomized Clinical Study","volume":"11","author":"Piquero\u2010Casals J.","year":"2025","journal-title":"Skin Appendage Disorders"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8421"},{"issue":"2","key":"e_1_2_12_29_1","first-page":"52","article-title":"An Open\u2010Label Evaluator Blinded Study of the Efficacy and Safety of a New Nutritional Supplement in Androgenetic Alopecia: A Pilot Study","volume":"10","author":"Nichols A. J.","year":"2017","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S521215"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5701"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12265"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400508"},{"issue":"5","key":"e_1_2_12_34_1","first-page":"558","article-title":"A Six\u2010Month, Randomized, Double\u2010Blind, Placebo\u2010Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self\u2010Perceived Thinning Hair","volume":"17","author":"Ablon G.","year":"2018","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/841570"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/549721"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114838"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8125081"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:22:05Z","timestamp":1782292925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jocd.70817"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70817","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70817"}}