{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:50Z","timestamp":1782294530134,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyaluronic acid (HA) fillers are widely used for lip augmentation and are generally associated with a favorable safety profile. While vascular complications are well recognized, non\u2010vascular neurological adverse events, including trigeminal neuropathic pain, remain underreported, particularly following procedures in anatomically lower\u2010risk areas such as the lips.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report a rare case of persistent trigeminal neuralgia\u2010like pain following HA lip augmentation and to highlight diagnostic and therapeutic considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 49\u2010year\u2010old woman developed persistent facial pain 10\u2009days after HA lip augmentation. Clinical evaluation included dental assessment, imaging studies, and high\u2010resolution ultrasound of the perioral region. Initial management with hyaluronidase, corticosteroids, and non\u2010steroidal anti\u2010inflammatory drugs was performed. Due to persistent symptoms, a neuropathic pain\u2010oriented treatment with pregabalin and palmitoylethanolamide (PEA) was initiated. Pain severity was assessed using a visual analog scale (VAS), and follow\u2010up was conducted over 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient presented with severe bilateral facial pain and paresthesia (VAS 7), refractory to conventional anti\u2010inflammatory treatment. Imaging excluded dental pathology and vascular complications, while ultrasound revealed localized post\u2010procedural tissue changes. Following initiation of pregabalin and PEA, a significant and sustained reduction in pain was observed (VAS 2 at 1\u2009month; VAS 1 at 3\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent trigeminal neuralgia\u2010like pain represents a rare but clinically relevant complication of HA lip augmentation. This case supports a neuropathic and neuroinflammatory mechanism and underscores the importance of early recognition and targeted treatment. Awareness of this complication may improve clinical outcomes and guide management strategies in aesthetic practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70822","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:29:21Z","timestamp":1775104161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistent Trigeminal Neuralgia\u2010Like Pain Following Isolated Hyaluronic Acid Lip Augmentation: A Case Report"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-3166","authenticated-orcid":false,"given":"Rocco Salvatore","family":"Calabr\u00f2","sequence":"first","affiliation":[{"name":"Spinal Cord Unit, IRCCS Centro Neurolesi \u201cBonino\u2010Pulejo\u201d  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Bonavita","sequence":"additional","affiliation":[{"name":"Otorhynolaringology Unit, \u201cGiuseppe Fogliani\u201d Hospital  Milazzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X14525035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101721872"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010024\u201003915\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13950"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12907"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12170"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102982.2007.01483.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104637.2010.00823.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.54843"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S540327"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:24:27Z","timestamp":1782293067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jocd.70822"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70822","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70822"}}